创伤性脑损伤生物学标记的临床研究进展.pdfVIP

2011年 第 38 MAGE一1are expressed in human glioblastomaand recognized [15]HernanR，FashehR，CalabreseC，eta1．ERBB2up—rega1． bycytotoxicTcells．CancerRes，2004，64(14)：4980— 1atesS100A4 and several otherprometastaticgenesinmedul— 4986． loblastoma．CancerRes，2008，63(1)：140—148． [9] MineoJF，BordronA，BaronciniM，eta1．LowHER2一ex— [16]ParkIH，RoJ，LeeKS，eta1．Trastuzumabtreatmentbe— pressing glioblastomas are more often secondary to anaplastic yond brain progression in HER2-positive metastatic breast transformation oflow—gradeglioma．JNeurooncol，2007，85 cancer．AnnOncol，2009，20(1)：56—62． (3)：281—287． 117] BravoMJ．Treatmentofbrainmetastasesin patientswith [10]Gilbe~sonRJ，BentleyL，HernanR，eta1．ERBBreceptor HER2+ breastcancer． Adv Ther，2009，26 Suppl 1： signaling promotesependymomacellproliferationand represents S18一S26． apotentialnoveltherapeutictargetforthisdisease．ClinCanc- [18] Polkingho133．WR，TarbellNJ．Medulloblastoma：tumorigene- erRes，2009，8(10)：3054-3064． sis，currentclinicalparadigm ，and efforts to improve risk [11]MeurerRT，MatinsDT，HilbigA，eta1．Immunohistoehem— stratification．NatClinPractOncol，2007，4(5)：295． icalexpressionofmarkersKi一67，neun，synaptophysin ，p53 304． and HER2 in medulloblastomaand itscorrelationwithclinico． [19]EmanuelSL，HughesTV，AdamsM，eta1．Cellularandin pathological parameters． Arq Neuropsiquiatr， 2008 ， 66 vivoactivityofJNJanonquinazolinepan—ErbB (2B)：385-390． kinase inhibitorthatcrosses the blood—brain barrierand dis— [12]LinNU，WinerEP．Brainmetastases：theHER2paradigm． plays efficacy against intracranial tumors． Mol Phamr acol， ClinCancerRes，2007，13(6)：1648—1655．