药物合成实验之环丙烷1,1-二元羧酸.pptVIP

环丙烷1，1-二元羧酸的制备 实验内容 Experiment content To?a?1L?solution?of?50%?sodium?hydroxide（氢氧化钠）?,mechanically?stirred(机械搅拌)?in?a?2L,three?–necked?flask（三颈烧瓶）,was?added?,at?25。C，114.0g?(0.5mol)?of?triethylbenzyl?ammonium?chloride（氯化铵）.? 在装有磁力搅拌子的2L三颈烧瓶中加入1L50%的氢氧化钠溶液、114.0g的氯化铵在25。C条件下反应。 To?this?vigorously?stirred?suspension?was?added?a?mixture?of?80.0?g?(0.5mol)?of?diethyl?malonate（丙二酸二乙酯）?and?141g?(0.75mol)?of?1,2-dibromoethane（二溴乙烷）?all?at?once?.在搅拌下立即加入80g的丙二酸二乙酯和141g的1,2-二溴乙烷. ◆ ◆ 实验内容 Experiment content The?reaction?mixture?was?vigorously?stirred?for?2?hours?.?The?contents?of?the?flask?were?tran