1-灵芝多糖对CT26荷瘤小鼠的免疫调节作用-main.pdfVIP

Food Chemistry 136 (2013) 1213–1219 Contents lists available at SciVerse ScienceDirect Food Chemistry journal homepage: www.elsevier .com/locate/foodchem Immunomodulatory effect of Ganoderma atrum polysaccharide on CT26 tumor-bearing mice Shenshen Zhang, Shaoping Nie ⇑, Danfei Huang, Wenjuan Li, Mingyong Xie ⇑ Department of State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, China a r t i c l e i n f o a b s t r a c t Article history: Ganoderma atrum has attracted great attention for its antitumor activity. However, the mechanism Received 26 April 2012 remains unclear. A G. atrum polysaccharide (PSG-1) showed pronounced antitumor activity in this study. Received in revised form 23 July 2012 PSG-1 did not kill CT26 cells directly, but inhibited the proliferation of CT26 cells via the activation of Accepted 29 August 2012 peritoneal macrophages (MU). In vivo, PSG-1 significantly suppressed the tumor growth in CT26 Available online 18 September 2012 tumor-bearing mice. The treatment caused a significant increase in the immune organ index and the phagocytosis of macrophages. The production of TNF-a, IL-1b and nitric oxide also increased. Further- Keywords: more, we found that PSG-1 acted on Toll-like receptor (TLR) 4, signaled through p38 MAPK pathway, then Antitumor