12072_2008_Article_9111人脂联素.pdfVIP

Hepatol Int (2009) 3:364–370 DOI 10.1007/s12072-008-9111-0 ORIGINAL ARTICLE High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection Chun-Jen Liu Æ Pei-Jer Chen Æ Ming-Yang Lai Æ Chen-Hua Liu Æ Chi-Lin Chen Æ Jia-Horng Kao Æ Ding-Shinn Chen Received: 11 July 2008 / Accepted: 30 October 2008 / Published online: 2 December 2008 Asian Pacific Association for the Study of the Liver 2008 Abstract Methods Serum adiponectin and hepatitis B viral factors Purpose Adiponectin possesses anti-inflammatory and were cross-sectionally assayed in 280 patients with chronic insulin-sensitizing properties. Little is known about the role hepatitis B virus (HBV) infection including 120 patients of adiponectin in hepatitis B-related liver disease. with chronic HBV infection, 40 patients with cirrhosis, and 120 patients with hepatocellular carcinoma (HCC); 116 healthy adults were used as controls. The dynamics of serum adiponectin level was also studied longitudinally in C.-J. Liu P.-J. Chen M.-Y. Lai C.-L. Chen 25 patients with hepatitis B e antigen (HBeAg) serocon- J.-H. Kao () D.-S. Chen version (SC). Graduate Institute of Clinical Medicine, National Taiwan Results We found that serum adiponectin level in University College of Medicine, National Taiwan University patients with chronic HBV infection was similar to that in Hospit