硫辛酸对大鼠急性肺损伤急性呼吸窘迫综合征模型的保护机制.pdfVIP

砌堕窒堡塑堕型篁丝!!童丝塑 ．C．．．1．．i．。n．．．i．．c．．a．．．1．．．．M．．．．．i，s—d—i—a，—g—n——o—，s——is—．．．．．．．．．M．．．．．i。．s．．t。．h．．．e．．r．．a．．．p．，．y．．．,．．F．．．．e．，．b，．．r．u．．．．a．．r．．y．．．．．2．．．0．．．0．．。8，—，。,．—V—o．．—1．．．．2，，．，1，—，,。．N．．．．o．．—．2— 蹴畿 缮驻毛；并茹：弱 硫辛酸对大鼠急性肺损伤／急性呼吸窘迫综合征模型的保护机制 ’ 庆400038) · 6me／kg尾静 脉注射诱发大鼠造成ALI／ABDS模型，LA组和GSH组分另q于注射LPS后o．5h注射LA和GSH各100mg／kg。注射后l、2、4和 6h观察血清肿瘤坏死因子(TNF—a)水平，6 h后处死大鼠，测定动脉血氧分压(PaO：)、血清脂过氧化物水平(LPO)、肺湿干比 (wet／dry ratio，W／D)、肺泡灌洗液(bronchoalveolar weight lavage 作用。 关键词：硫辛酸；呼吸窘迫综合征，成人；模型，动物 中图分类号：R563；R一33文献标识码：A 文章编号：1002-3429(2008)02-0006-03 ProtectiveEffectsofAntioxidative AcidonEndotoxin-inducedALI／ARDSinRats AlphaLipoic BIAN Medical of Weil，FENGYa—qin2，LUOYuan3(1．BethuneMilitary College，Shijiazhuang050081，China；2．GeneralHospital Lanzhou T“rd Medical MilitaryArea，Lanzhou730000，China；3．The 400038，China) Military University，Chongqing mechanismsof acidonendotoxin—inducedacute inrats LPSandto Abstract：Objective：Toexploreprotective Q—lipoic lunginjury by anewmedicaltreatmentin ALI／ARDSmodeswereinducedinmaleWisterrats in- provide ALI／ARDS．Methods：Experimental by of ratswere dividedintofour jeetionLPS(6’mr／ks)．Fortyrandomly groups：controlgroup(NSgroup)；ALI／ARDSgroup(LPS serum andGSH andGSHwereadministeredinhalfanhourafter ofLPSorNS．TNF·aofthe group)；LAgro