Wnt信号转导及其生物效应.pdfVIP

ISSN 中国生物化学与分子生物学报 2001 年 8 月 ( ) CN 　113870Q Chinese Journal of Biochemistry and Molecular Biology 17 4 :415～419 ·综　述· Wnt 信号转导及其生物效应 张 　平 (浙江中医学院病理学教研室 ,杭州　310053) 摘要 　Wnt 蛋白与其下游效应物构成一组重要的信号转导通路. 信号转导过程包括 :Wnt 首先激活 ( ) ε β β 细胞表面受体佛力子 FZ ,活化的 FZ 将通过 Dvl 、CKI 抑制糖原合成酶激酶3 ,继而拮抗 链结素 (β ) β β cat 催毁器的作用 ,使胞浆中 cat 积聚并进入核内. cat 在核内与转录因子 LEFTCF 协作 ,激活 控制胚胎发育和细胞命运的靶基因 ;活化的 FZ 还经激活JNK 及 Flamingo 来影响细胞骨架的聚合 , 以决定细胞的平面极性及纺缍体定位. β 关键词 　Wnt ,佛力子 , 链结素 ,泛素蛋白酶体 ,信号转导 ,生物效应 中图分类号 　Q73 Wnt Signal Transduction and Its Biological Effects ZHANG Ping ( Department of Pathology , Zhejiang College of Traditional Chinese Medicine , Hangzhou 310053 , China) Abstract 　Wnt proteins together with their downstream effectors form a set of important signal pathways. The processes of their transduction include :Wnt first activates cell surface receptor Frizzled ,activated Frizzled in hibits activity of GSK3 β ε β by Dishevelled and CKI and then antagonizes role of catenin , destruction machin ery followed by β catenin , accumulating in cytoplasm and then entering the nucleus where it cooperats with LEFTCF to activate target genes controlling embryogenesis and cell fate ,and activated Frizzled also activates JNK pathway or Flamingo which effec