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Catal Lett (2014) 144:1289–1295 DOI 10.1007/s10562-014-1254-0 Asymmetric Transfer Hydrogenation of Aromatic Ketones Catalyzed by New Chiral C2-Symmetric Bis(sulfonyl) tetraaza Ligands Complexed with [Ru(g6-p -cymene)Cl ] in Water 2 2 Xungao Liu • Tian Zhang • Yingying Hu • Liang Shen Received: 3 January 2014 / Accepted: 2 April 2014 / Published online: 18 April 2014 Springer Science+Business Media New York 2014 Abstract In this report, a new series of C2-symmetric optimize the conversion and stereoselectivity of the cata- bis(sulfonyl) tetraaza ligands were synthesized from lytic system. (1S,2S)-1,2-diarylethylenediamine analogues and tested in The previous study in our group has provided a useful the asymmetric transfer hydrogenation (ATH) of aromatic insight for the design of efficient C2-symmetric chiral ketones by complexing with [Ru(g6-p -cymene)Cl ] tetraaza ligands (Fig. 1) [22]. Inspired by these results, we 2 2 employing sodium formate as hydrogen source in neat aimed to explore the electronic and steric effects on the water. A moderate to excellent conversion ( *99.8 %) and catalytic activity of ligands by developing a new set of overall satisfying enantioselectivity ( *92.8 %) were bis(sulfonyl) tetraaza ligands derived from (1S,2S)-di- obtained with varied electronic and steric effects of the phenylethylenediamine complexed with [Ru(g6-p - substituents on ligands and substrates. cymene)Cl ] and used in the ATH of acetophenone and