妊娠期巨细胞病毒感染诊断研究进展.pdfVIP

10 国际妇产科学杂志2013 年2 月第40 卷第1 期 J Int Obstet Gynecol February 20 13 Vol. 40 No. 1 综 述 妊娠期巨细胞病毒感染诊断研究进展 吟 沈凤贤综述 吕时铭 审校 揖摘 要铱 人巨细胞病毒渊cytomegalovirus CMV冤是最常见的先天感染病毒遥 胎盘细胞感染CMV 致胎盘病理改变 和胎儿感染CMV 导致严重的出生缺陷 对优生优育是严峻的挑战 长期以来各国学者一直致力于先天性CMV 感染及 其出生缺陷的防治研究遥妊娠妇女的 发感染或者继发感染均可引起先天性CMV 感染 妊娠前或者妊娠期CMV 血清 学筛查对于发现高危妊娠妇女非常重要 IgG 抗体亲和力测定方法为现有IgG 和IgM 检测提供了很好的信息补充遥 一 旦确诊妊娠妇女感染CMV 胎儿预后的评估非常重要 羊水CMV 检测和影像学检查一方面可以用于宫内感染的诊 断 另一方面也可以提供一定的胎儿预后信息遥 揖关键词铱 巨细胞病毒曰 妊娠曰 产前筛查曰 产前诊断 Update on Diagnosis of Cytomegalovirus Infection During Pregnancy SHEN Feng-xian L Y U Shi-ming. Women 忆s Hosp ital School of Medic ine Zhej iang Unive rs ity H angz hou 310006 China Corresp onding author: L Y U Shi-ming E-mail: lusm@zj u.edu.cn 揖Abstract 铱 Human cytomegalovirus 渊CMV冤 is the most common pathogene of congenital viral infection. Pathological changes of placenta resulted from CMV infection of placenta combined with cytopathy caused by fetal infection induce serious birth defects which will be severe challenges to aristogenesis rearing of the state. For a long time scholars in different countries have been working together to prevent and control symptomatic congenital CMV infection. Both primary and secondary maternal infection can cause intrauterine transmission. CMV serological screening is important for identifying high risk pregnancy. HCMV-specific IgG avidity assay provides more information besides IgG and IgM testing. Once we prove maternal CMV infection fetal prognosis assessment is most critical. Amniotic fluid CMV-DNA detection and imaging studies could be used to diagnosis of intrauterine infection and fetal prognosis. 揖Key words 铱 Cytomegalovirus; Pregnancy; Prenatal screening; Prenatal diagnosis 渊J Int Obs tet Gynecol 20 13, 40 院10- 13 2