附睾特异性基因的表达与调控.pdfVIP

71 12 1 Vo.l 12 N o. 1 2006 1 National Journal of Andrology Jan. 2006 曹少锋 ; 徐 晨 ( , , 200025) : , , , , (), , : ; ; : Q492. 4; Q7 6 : A : 1009-3591 ( 2006) 01-0071-04 Specialized G ene Expression and Regulation in the Epididym is CAO Shao-feng, XU Chen D epartmentof H istology and Embryology, ShanghaiJiaoTong University Schoolof M edicine, ShanhaiKey Laborato- ryf or eproductiveM edicine, Shanghai 200025, China Corresp ondence to: XU Chen, E-mail: ChenX@ shsmu. edu. cn Abstract: The epid idym is is a single and h ighly convoluted tubule system in m amm als. The epithelium is the major com partm ent for ep ididym al function. Proteins synthesized and secreted by epididym al ep ithelium provide a special and ever-changing lum inal flu id en- vironm ent for sperm as they progress through the ep id idym is, wh ich m akes sperm ach ievem otility and u ltmi ately results in sperm func- tional maturation. Specialized genes expressed in the epid idym is have regional-specific characteristics. They are regulated by androgen and /or testicu lar factors and present spatial and tempa-l specialized expression pattern in postnatal developm ent, all these h int that they p lay mi portant and un ique roles in epid idym is. N atl J A ndrol, 2006, 12 ( 1 ): 71-74 K ey words: epididym is; gene express ion; regu lation , 1 () , , 1. 1 区域特异性 Northern() , mRNA HE2B /CEAPI(GPX ) , ( cystatin- related epididymal