New mechanism for neural stem cell maintenance in early embryos.pdfVIP

维普资讯 囝W盯CH NewmechanismforneuraIstem cellmaintenanceinearlyembryos eamingupwithco—workers thatthemaintenanceoftheNSC proneuralgenesand share an from Japan，UK andUS， poolisessentialfornomr alneural overlapping expression pattern TCASbiochemistshavere— develoPm ent． Precocious withHes1．OverexpressiOnofId2 vealedanovelmechanism formain— neurogenesiscouldreducethenum— in the chick hindbrain tainingneuralstem cellsin early berofneuronsandleadtoalackof upregulatesHeslexpression and embryos．Theirworkwaspublished glialtypes，impedingthenomr alde— inhibitsproneuralgeneexpres— on the6 AugustissueofCell velopmentofthecentralneural sionandneuronaldifferentiation． Development． system．Althoughprogresshasbeen By contrast，HesJ expression Neuralstemcells(NSCs)area madein identifyingsomecompo— decreases，proneuralgeneexpres— typeofstem cellsthatresidesinem— nentsofthegeneticprogram in— sionexpands，andneurogenesis bryonicandadultneuralsystems volved in regulating N SC occursprecociouslyin theIdex— with thecapacityofself-renewal maintenance，thedetailedunderly— pression inhibited chick and anddifferentiation．They cangive ingmechanismsstillremainlargely mouse embryos．M echanistic risetonewnervecells(called unknown． studiesshow thatIdproteinsin— neurons)andothercellsthatsup— During studiesoftheneural teractdirectlywithHeslandre— portnervecells(calledglia)，form— developmentofchickandmouse lease thenegativefeedback au— ingacompletecentralneuralsys— emb