GGG孟鲁司特对肺炎支原体感染哮喘儿.docVIP

孟鲁司特对肺炎支原体感染哮喘儿 尿白三烯水平的影响 花元清　张爱青　甘卫华　刘一平 【摘要】　目的　探讨孟鲁司特对肺炎支原体(MP) 感染对哮喘患儿尿白三烯水平的影响。方法 哮喘组患儿200 例和对照组健康儿童50 例,采用被动凝集法检测MP2IgM 抗体。哮喘患儿根据 MP2IgM 抗体检测结果分为4 组:A 组32 例MP2IgM 阳性,常规治疗+ 孟鲁司特治疗;B 组32 例 MP2IgM 阳性,常规治疗;C 组32 例MP2IgM 阴性,常规治疗+ 孟鲁司特治疗;D 组32 例,MP2IgM 阴性,常规治疗。应用EL ISA 法定量测定患儿治疗前后尿白三烯水平。结果　MP2IgM 抗体阳性 (A、B 组) 患儿治疗前尿白三烯水平明显高于MP2IgM 抗体阴性(C、D 组) 患儿[ (0151 ±0126) ng/ ml vs. (0138 ±0111) ng/ ml ] ( P 0101) 。A 组和C 组治疗后尿白三烯水平均比治疗前明显降低 [ (0125 ±0120) ng/ ml vs1 (0150 ±0126) ng/ ml ] ( P 0101) 和[ (0122 ±0110) ng/ ml vs1 (0135 ±0115) ng/ ml ] ( P 0105) 。治疗后A 组尿白三烯水平明显低于B 组[ (0125 ±0120) ng/ ml vs1 (0142 ± 0115) ] ( P 0101) 。结论　肺炎支原体感染可明显地诱导哮喘患儿体内白三烯水平的升高;孟鲁司 特可以降低肺炎支原体感染的哮喘患儿体内尿白三烯水平。 【关键词】　　支气管哮喘;肺炎支原体;尿白三烯;孟鲁司特 【中图分类号】　R562 　　【文献标识码】　A 　　【文章编号】　025323685 (2009) 0620672203 Effect of montelukast on urine leukotrienes in asthmatic childrenwith mycoplasma pneumoniae infection HUA Yua nqing , ZHANG Aiqing , GAN Weihua , et al . Depa rtment of Pediat rics , Na njing Maigaoqiao Hospital , Na njing 210011 , CHINA 【Abstract】　Objective 　To investigate the effect of montelukast on urine leukot rienes in asthmatic children with mycoplasma pneumoniae (MP) infection. Methods 　The serum MP2IgM antibody was detected by passive agglutination in 200 asthmatic cases and 50 normal subject s. According to the result s of MP2IgM antibody examination , asthmatic cases were divided into four groups of A (32 cases) with MP2IgM positive and the t reatment of montelukast ,B (32 cases) with MP2IgM positive and the conventional t reatment without montelukast , C ( 32 cases) with MP2IgM negative and the t reatment with montelukast , and D ( 32 cases ) with MP2IgM negative and the conventional t reatment without montelukast . The urine leukot riene level before and after t reatment was detected by EL ISA. Results 　Urine leukot riene in MP2IgM positive cases (group A and B) was higher than that in the MP2IgM negative (group C and D) before therapy [ (0151 ±0126) ng/ ml vs1 (0138 ±0111) ng/ ml ] ( P 0