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1048 基础医学与临床 BasicClinicalMedicine 2014．34(8) ethylationofCpGislandsandlossofexpressionofthe14—3— poorsurvival inpatientswith esophagealsquamouscell 3sigmageneinhumanhepatocellularcarcinoma[J]．On— carcinoma[J]．DigDisSci，2010，55：2552—2560． cogene，2000，19：5298—5302． [12]OkumuraH，KitaY，Yokomakura，eta1．Nuclearexpres— [8]PulukuriSM，RaoJS．CpGislandpromotermethylationand sionof14_3_3sigmaisrelatedtoprongosisinpatientswith silencingof14-3—3sigma gene expression in LNCaP and esophagealsquamouscellcarcinoma [J]