Cytokine Signaling.ppt

Cytokine Signaling Types of receptors Protein tyrosine kinase receptors with intrinsic kinase activity Insulin, EGF, PDGF, CSF-1 etc. Protein serine kinase receptors with intrinsic kinase activity MIS, TGFb, activin, inhibin etc. Receptors without intrinsic kinase activity This is the large, heterogeneous group called the cytokine receptor super family G-protein coupled receptors and ion-gated receptors Types of receptors Protein tyrosine kinase receptors PTK receptor activating MAP kinase pathway PTK receptor activating Pi-3 kinase pathway SH2 domain containing protein: recognition of phos