中国男性精神分裂症患者吸烟精神病理学认知功能和治疗相关不良反应的病例对照研究.pdfVIP

· 283 · 中国药物依赖性杂志(ChinJDn】gDepend)2009．18(4)：283—2塑 [论著] CIGARETTE SMOKING ，PSYCHOPATHOLOGY，COGNITIVE FUNCTION AND 匝DICATION SII)EEFFECTSIN CHINESE MALE SCHIZOP】田 ：A CASE—CONTROL STUDY ZHANGXiangyang一 。CAOLianyuan，CHENDachun，QILingyan，CHENSong2， WANGFan，XIUMeihong，WUGuiying，LULin ，ThomasRKOSTEN ’ (TheMenningerDepartmentofPsychiatryandBehavioralSciences，BaylorCollegeofMedicine， Houston，Texas， S．A) 。(TheCenterforBiologicalPsychiatry，BeijingHuiLongGuanHospital，Beijing，PRChina) (NationalInstituteon Dependence，PekingUniversity，Bejiing，China) smokingratesare3-4 timeshigheramong AmericannadEuropean schizophrenicsthancommunitycontrols，andareassociatedwiht reducednegativeandextrapyramidalsyurp- tomsnadimprovedcognitivefunctioning．Th eaims ofthepresentstudyweretoexaminehteseclinicalassocia- fionsinChinesecshiozphrenics．Methods：Wecompared776malecshizophrenicsot560malecomm uniyt con- troisonhteFagerstromTestforNicotineDependence(FTND)nadonhteRepentabe／BatteryfortheAssessment ofNeuropsychologicalStatus(RBANS)．Patients alsowereadministeredthePositiveand Negative Symptom Scale(PANSS)，hteSimpsonandAn SympotmRatingScale(SAES)，andhteAbnormal InvoluntaryMovementScale(AIMS)．Results：Lifetimesmokingwashigherforhteschizophrenicsthancom- munitycontrols(79％ VS63％)，andheavysmokingshowedagreaterdifferencefromcontrols(61％ VS 31％)．ThePANSSnegativesymptomandSAESParkinsonismscoreswerelowerincurrentsmokersthan non—smokers．CognitivefunctioningonhteRBANSwasworstforsmokingschizophrenics，htenbetterfor non—smokingschizophrenics，thensmokingcontrols，andhtennon—smokingcontrolswhoscoredb