AntidepressantsandSexualDysfunction-University：大学的抗抑郁药和性功能障碍.ppt

 American Society Clinical Psychopharmacology Teaching Points Many psychiatric drugs are associated with sexual dysfunction Drug-induced sexual dysfunction may be an unspoken cause of treatment non-compliance In most cases, sexual side effects can be medically managed Abbreviated Outline A. Co-morbidity of sexual dysfunction and psychiatric disorders B. Need for direct inquiry C. SSRIs and sexual dysfunction D. Benzodiazepines and SD E. Lithium and SD Anticonvulsants and SD .Antipsychotics and SD Pre-Lecture ExamQuestion 1 Which antidepressants appears to have a very low incidence of drug-induced sexual dysfunction? 1. paroxetine 2. fluoxetine 3. serteraline 4. bupropion Question 2 Which drug has been shown in double-blind trials to reverse SSRI-induced sexual dysfunction? 1. mirtazapine 2. yohimbine 3. gransitron 4. sildenafil Question 3 Which antipsychotic appears to have the lowest incidence of drug-induced sexual dysfunction? 1.olanzapine 2.risperidone 3.thioridazine 4. haloperidol Question 4 True or false Case reports suggest that sidlenafil may be helpful in reversing antipsychotic-induced sexual dysfunction. True False Question 5 Studies indicate that which of the following may be successful in reversing SSRI-induced sexual dysfunction. 1. 15 mg buspirone 2. 60mg buspirone 3. 50mg amantadine 4. 15mg yohimbine Sexual Co-Morbidity Major depressive disorder Obsessive compulsive disorder Posttraumatic stress disorder Anorexia nervosa Schizophrenia Social phobia Panic disorder History 1. 1971 :first report of female orgasm delay on monoamine oxidase inhibitors 2. 1985 :double-blind study indicated high rate of orgasm/libido problems on both phenelzine and imipramine 2. 1987 :Double-blind study indicated orgasm problems on benzodiazepines 3. 1976-Reports of orgasm delay on antipsychotics Sex Differences PDR initially only indicated that sexual problems occurred in males Early clinical reports indicated that