HPLC测定帕金森模型小鼠脑中D_丝氨酸的含量.pdfVIP

27 2 : V o l 27 No 2 2009 6 J our nal o f Gu angx i N o rm al U niv ersity: Na tur al Science Edition J un 2009 - HPL C D 1 2 1 1 , , , ( 1 , 54 1004; 2 , 54 1004) : ( ) - -- -( ) , -- OP A N D IBD C , , , D -( D -Ser) Ser 20 m in D -Ser 30 1 500 nmol/ L , ( R = 0 999 5) 3( S / N = 3) , D -Ser 10 nmol/ L ( P arkin son s disease , PD ) - , , - , D Ser D Ser , D -Ser P D : ; ; ; ; ; D - : O652 63: A : 100 1-6600( 2009) 02-006 8-04 D -( D -Ser ) , , -- -( - - - , ) , N D N m et hyl D asp art ate recept or N MDA r N M DA r [ 1] , N M DA r D -Ser , D -Ser [ 2, 3] D -Ser [ 4] , ( P arkin so ns dis - ease, PD) , N M DA r ( glut amic acid, Glu) [ 57] , , , [ 8] P D N MDA r ( M K -80 1, CPP ) PD [ 9] , N M DA r PD N MDA r D -Ser P D , - D Ser PD D -Ser , ( o-pht halaldehyde, OPA ) - , [ 10, 11] , : -- - -- ( ) -( ) [ 12] - - N L N L D IBC OPA IBD C -Ser , P D D -Ser , P D 1 1 1 L C-10A T V P ( ) , L C-10A T , , CLA SS-V P 5 03