MMP_11在胃癌患者血清中的表达及临床意义.pdfVIP

5中国癌症杂志6 2007 17 12 968 CH INA ONCOLOGY 2007 Vol. 17 No. 12 M MP-11在胃癌患者血清中的表达及临床意义 v * * , , 100036 [ ] : 11( MM P-11) , , MMP-11, 11(MM P-11) : 2005 3) 2007 2 130 , - MMP-11 mRNA 20 : MMP-11mRNA 5% , ( 68. 4% ); MMP-11( 44 ? 27) ng/m ,l ( 3 ? 3) ng /m l; 130, 30; () 30 , MM P-11 ( 5 1? 27) ng/m ,l MMP-11( 27 ? 28) ng/m l; MMP-11mRNA : MMP-11 , , (), / [ ] 11; ; : R735. 2; R730. 43 : A : 1007-3639( 2007) 12-0968-05 Expression ofM MP-11 in serum of gastric cancer and its significance YAN Dong, SHEN Lin, LV You-yong (Departm ent of D igestiveD isease, Laboratory of Molecular ncology, Beij ing CancerHosp ital, Beij ing 100036, China) Corresp ondence to: SHEN Lin E-mai:l lin100@ medmai.l com. cn [Abstract] Background and purpose: M trix m et lloprotein se11(MMP-11) is n interesting member of the MMP f m ily, nd its overexpression h s been dem onstr ted in hum n c ncers such s non-sm ll cell lung c ncer nd oesoph ge l denoc rcinom . Furtherm ore, strong MMP11 gene expression is correl ted w ith both incre sed ggressiveness of tum ors nd poor clin ic l outcom e, but there w s no rel ted reports on g stric c ncer. W e focussed our study on the signific nce ofMMP-11 expression in g stric c ncer. Methods: MMP-11w s selected nd confirm ed t both mRNA nd protein level in 130 c ses of g stric c ncer serum specmi en by RT-PCR, enzym e-linked-mi m uno-sorbent- ss y ( ELISA ) techn iques, re- spectively. Results: The tot l positive r tes