川芎嗪注射液治疗缺血性中风急性期随机对照实验的系统评价_李可建.pdfVIP

2006 17 10 LISH IZHEN MEDICINE AND MATERIA MEDICA RESEARCH 2006 VOL. 17NO. 10 李可建 (, 250014) : 系统评价川芎嗪注射液治疗缺血性中风急性期的临床疗效及安全性 搜集川芎嗪注射液治疗缺血性 中风急性期随机对照实验文献, 筛选合格研究, 应用 Jadad评分法进行质量评价, 运用异质性检验M eta-分析敏感性分 析等方法统计相关数据 有 4 项符合纳入标准, Jadad评分显示所有研究得分均低于 3分, 属低质量文献M eta-分 析结果显示, 与空白对照组比较, 总有效率 RR合并 = 1. 45, 其 99% 可信区间为 ( 1. 24, 1. 70) ; 神经功能缺损评分比较的 WMD合并 = -4. 9 , 99% CI为(- . 21, -1. 74)敏感性分析显示 M eta-分析结果稳定可靠 系统评价结果显示川芎嗪 注射液治疗缺血性中风急性期有效; 无相关报道, 故安全性尚不明确由于纳入研究质量普遍低, 降低了系统评价结论 的可靠性要进一步验证川芎嗪注射液治疗缺血性中风急性期的疗效及安全性, 尚需进行设计合理执行严格多中心 大样本且随访时间足够的随机对照实验 : 川芎嗪注射液; 缺血性中风; 急性期; 随机对照实验; 系统评价 : R2 5. 6 : A : 100 -0 05( 2006) 10-1 74-02 A SystematicReview ofLigustrazine Injection forAcute Ischaem ic Stroke LIK e-jian (Shandong Un ivers ity of Trad itional Ch ineseM ed icine, J inan, Shandong, 250014, Ch ina ) Abstract: Objective To evaluate efficacy and safety of Ligustrazine Injection for acute ischaem ic stroke. Methods Random ized controlled trails ( RCTs) of Ligustrazine Injection for acute ischaem ic stroke w ere iden tified, eligible stud ies w ere included, the m ethodological quality of inclusive trailsw as assessed by Jadad scale. H eterogeneity test, M eta-analys is and sensitivity analysis w ere used to analyse data. Results FourRCTswere included, w ith all trails of low m ethodological quality. Ligustrazine injection vs no-treatm ent control, M eta-analys is indicated that relative risk of overall effective rate w as 1. 45 [ 99% CI( 1. 24, 1. 70 ) ], w eighted m ean d ifference of mi proving neurological mi pairm ent w as-4. 9 [ 99% CI(- . 21, -1. 74) ]. Sensitivity analysis ind icated that result ofM eta-analysiswas cred ible. onclusion This systematic review showed that Ligustrazine Injection i