金纳米簇偶联两亲性嵌段共聚物作为靶向药物载体.doc

金纳米簇偶联两亲性嵌段共聚物作为靶向药物载体 陈桐，朱玲，赵彤，李媛媛，徐双，张海霞* 兰州大学化学化工学院，730000，兰州 E-mail: zhanghx@lzu.edu.cn 合成了的纳米材料作为靶向药物载体，其结构为金纳米簇为核并且叶酸偶联的两亲性嵌段共聚物作为壳，其中聚乳酸为内壁，叶酸偶联的硫酸化多糖为外壁。抗癌药物喜树碱(CPT)作为一种疏水性模型药物。，载体依靠载体表面叶酸介导的细胞内吞作用具有靶向给药作用。荧光影像实验表明，药物载体能够在细胞水平上进行跟踪，为进一步的研究药物传递机理提供可能。Fig. 1 Schematic illustration of the Au Fig. 6 TEM images of (A) and (D) Au NCs; (B) and (E) NCs-PLA-GPPS-FA copolymers. Au NCs-PLA-GPPS-FA-1 copolymers；(C) and (F) Au NCs-PLA-GPPS-FA-2 copolymers. 关键词：金纳米簇；药物载体；多糖；毒性 参考文献 [1] Xie, J.P.; Zheng, Y.G.; Ying, J.Y. J. Am. Chem. Soc. 2009, 131, 888. [2] Zhu, M.; Aikens, C. M.; Hollander, F. J.; Schatz, G. C.; Jin, R. J. Am. Chem. Soc. 2008, 130, 5883. Gold nanoclusters-conjugated amphiphilic block copolymer for tumor-targeted drug delivery Tong Chen, Ling Zhu, Tong Zhao, Yuanyuan Li, Shuang Xu, Haixia Zhang* Department of Chemistry, Lanzhou University, 730000, Lanzhou Two kinds of multifunctional nanocarriers of gold nanoclusters (Au NCs) as core and folate (FA)-conjugated amphiphilic hyperbranched block copolymer as shell based on poly(L-lactide) (PLA) inner arm and FA-conjugated sulfated polysaccharide (GPPS–FA) outer arm (Au NCs-PLA-GPPS-FA) were synthesized for targeted anticancer drug delivery. The anticancer drug, camptothecin (CPT) was used as a hydrophobic model anticancer drug. The release results indicated that nanocarriers had excellent controlled release behavior and very low cytotoxicity. Furthermore, nanocarriers gained specificity to target some cancer cells due to the enhanced cell uptake mediated by FA moiety. The fluorescent images studies showed that the nanocarriers could track at the cellular level for advance therapy.