苦豆碱的抗炎、抗变态反应作用，httpwwwcqvip.pdfVIP

360 中国药理学报 Acfa Pharmaco[ogicaSini~ 1989Jnl，10 (4) ：360—365 苦豆碱 的抗炎、抗变态反应作用， 周重楚、高洪波、孙晓波、师海-皮、刘 威、袁惠南 、王忠效 (吉林省中医中药研究院 长春 130021，中国) Anti-inflammatory and anti-allergic action of aloperine ZhOU Chong—Chu，GAO Hong-Bo，SUN Xalo-Bo—SHIHai-Bo—LIU W ei—YUAN Hui-Nan W ANG Zhong-Xiao (Academy TraditionalMed~ine＆ MateriaMedieao／JilinPro~nc~，Changclum J3OOSJtCh,：na) AB ACT A loperine．an alkaloid isolated tisand the contentofimmune complex in from so rn aloFvcuroidcs L． showde a serum of rats with Arthus reaction．But marked suppressive effect on theswelling ithad ccrtain inhibitory effecton thePCA oftheratshind paw inducedby injecting reaction and sginificant inhibitory effect carrageenin，macostatin． PG E，．histamine． upon such allergic reaction asA 11husreac- 5一HT，on the rats scald oedema inducde tion， reversible passive Arthus reaction， by’scalding itshind paw ．and on the jn— the delayde hypersensitivity reaction indu— clea0edpermeability ofcapillariescaused by cedby tuberculin in eats and adjuvant histamine and the leukocyttc mjgratory arthritis． response．Theswelling induedbyinjecting KEY W ORDS alope tine； inflammatton； carrageenin into thehind paw ofadrenole． allergy： non-steroidal anti-inflam matory ctomizde latswasstillsignificantlyinhibited． Noticeably．alope rine ~duced the con． agents tentof PGE and histam ine in the ex~alte 撮薹 苦豆碱 (aloperine)对多种致炎剂 I起的急性炎 formde afterinjecting carrageenin anddex- 症和Ⅲ， 17型变态反应及佐剂关节炎均有显著的抑制 tran into the rats hind paw ， and in— 作用．其抗炎、抗变态反应作用不依赖于垂体一肾上腺 creased the stability ofred cel1menbranes． 皮质系统，主要与其抑制 WBC游走 ，稳定溶酶体 膜 the activity ofcataalse (CAT) in hepatic 促进自由基清除，抑制PG、组胺、淋巴因子等炎症介 tissu