PDS型功能性消化不良患者胃排空的研究.docVIP

PDS型功能性消化不良患者胃排空研究 　　作者：张兰,李胜棉,姚树坤　　作者单位：石家庄市，河北医科大学第四医院消化内科;北京中日友好医院 　　【摘要】目的 研究餐后不适综合征(PDS)型功能性消化不良(FD)患者与健康人胃排空的差异。方法 按照罗马Ⅲ诊断标准，选择PDS型FD患者34例纳入试验组，健康志愿者21例纳入对照组。对所有受试者进行核素胃排空检测，观察胃半排空时间(GET1/2)和120 min胃排空率(GE120)。结果 试验组GET1/2 (106±26)min高于对照组GET1/2(78±14)min，2组间差异有统计学意义(t=5.066，P0.01);试验组GE120(56±13)min低于对照组GE120 (71±11)min，2组间差异有统计学意义(t=-4.221，P0.01)。但是试验组症状积分与胃排空之间无相关性(P0.05)。结论 PDS型FD患者较健康人易存在胃排空延迟。 　　【关键词】 功能性消化不良,餐后不适综合征;胃排空;核素;胃半排空时间;胃排空率 　　【Abstract】 Objective To investigate the difference of gastric emptying between the patients with post prandial distress syndrome (PDS) and healthy subjects. Methods According to Rome Ⅲ standard，34 PDS patients in experiment group and 21 healthy subjects in control group were performed by gastric emptying. The gastric emptying halftime(GET1/2) and gastric emptying rate at 120 minutes(GE120) were detected as gastric emptying parameters. Results As compared with that in control group,the gastric emptying time was delayed significantly in experiment group,with GET1/2 (min) of (106±26),as compared with (79±14) in control group (P0.01). As for GE120 (%),which was (56±13) in experiment group vs (71±12) in control group(P0.01). However as for PDS patients，there was no correlation between patientssymptom scoring and gastric emptying rate (P0.05). Conclusion As compared with healthy subjects，the patients with PDS are easier to have gastric dyskinesis. 　　【Key words】 functional dyspepsia; postprandial distress syndrome; gastric emptying; nuclide; gastric emptying halftime; gastric emptying rate 　　功能性消化不良(FD)是一组临床常见的综合症候群，具有慢性、反复发作的病程特点。据报道[1]，人群消化不良的发病率在21%～40%,其中40%～70%为FD。FD的病因及发病机制迄今尚无定论，随着对FD认识的不断深入，罗马Ⅲ学术委员会对FD的诊断提出新标准，并根据不同的病理生理学异常为基础又将FD分为两种亚型[2]，即上腹痛综合征(EPS)和餐后不适综合征(PDS)。本研究对以餐后饱胀、早饱为主要症状的PDS型FD患者的胃排空进行检测，以健康人作对照，明确PDS型FD患者是否存在胃动力障碍，探讨其发病机制，指导临床治疗。 　　1 资料与方法 　　1.1 一般资料 　　选择河北医科大学第四医院消化门诊的PDS型FD患者34例为试验组，男14例，女20例;平均年龄(46±13)岁;平均体重指数(23.0±3.3) kg/m2。入选标准：根据罗马Ⅲ[2]分类体系中对PDS的诊断标准进行判断是否入选。选择健康人21