PCNA_CXCR4蛋白在青年乳腺癌组织中的表达及其意义.pdf

·346 · 实用癌症杂志 2008年 7 月第 23 卷第 4 期 　The Practical Jou rnal of Cancer, Ju ly 2008, Vol 23 ,No. 4 PCNA、CXCR4 蛋白在青年乳腺癌组织中的表达及其意义 刘桂平 　张良明　孙 　萍 　耿冬梅 　　【摘要 】　目的　探讨 PCNA 和 CXCR4 蛋白在青年乳腺癌肿瘤组织中的表达及其意义 。方法 　应用免疫组化 SP法 检测 24例青年乳腺癌的 PCNA、CXCR4表达 ,并与随机抽取的同期 50例中老年乳腺癌相比较 。结果 　24例青年乳腺癌 PCNA 、CXCR4表达率分别是 83. 3% 、70. 8% 。中老年组 PCNA、CXCR4 表达率分别是 64. 0% 、52. 0% 。青年乳腺癌 PC ( ) NA 、CXCR4表达率均高于中老年组 P 0. 05 。结论 　PCNA 及 CXCR4 高表达与青年乳腺癌组织分化差 ,侵袭性强有 关 。 　　【关键词 】　乳腺癌 ;青年女性 ;免疫组织化学 ;增殖细胞核抗原 ; CXCR4 蛋白 　　中图分类号 : R737. 9　　文献标识码 : A 　　文章编号 :(2008) The Expression an d S ign if ican ce of PCNA an d CXCR4 Prote in in Brea st Cancer T issue from Y oung W om en L I U Gu ip ing, ZHAN G L iang m ing, SUN P ing, et a l. 　M ed ica l colleg e of Q ing dao Un ivers ity, Q ing dao, 266000 　　【A b stract 】　O bjective　To evaluate the exp re ssion and sign ificance of PCNA and CXCR4 p rotein in b rea st cancer tissue s from young wom en. M ethods　The exp re ssion of PCNA and CXCR4 was evaluated by imm unoh istochem ical m ethod in tissue s from 24 young wom en w ith brea st cancer. 50 m iddle and old aged wom en w ith brea st cancer were u sed a s controls. Results　The po sitive rate s of CXCR4 and PCNA in the young group were 83. 3% and 70. 8% , and the po sitive rates of PCNA and CXCR4 in the con trol group were 64. 0% and 52. 0%. The po sitive rate s of CXCR4 and PCNA in the young group wa s h igher than that in the ( ) control group P 0. 05 . Con clusion　The h igh po sitive rate s of PCNA and CXCR4 in tissue s from young breast cancer p a tien ts are correlated w ith the h igh h isto logical grade and strong inva sion poten tials. 　　【Key words】　B rea st cancer; Young