Tyers M The GRID the General Repository for Interaction Datasets.pdfVIP

Nucleic Acids Research, 2006, Vol. 34, Database issue D535–D539 doi:10.1093/nar/gkj109 BioGRID: a general repository for interaction datasets 1 1 1,2 Chris Stark, Bobby-Joe Breitkreutz , Teresa Reguly , Lorrie Boucher , Ashton Breitkreutz1 and Mike Tyers1,2,* Ontario Cancer Institute, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9, 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 and 2Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8 Received September 23, 2005; Revised and Accepted October 17, 2005 ABSTRACT essential for interrogation of gene function, investigation of system level attributes and benchmarking of high throughput Access to unified datasets of protein and genetic (HTP) interaction studies. A number of interaction data- interactions is critical for interrogation of gene/ bases, including BIND (6), DIP (7), HPRD (8), IntAct (9), protein function and analysis of global network MINT (10), and MIPS (11), provide a variety of datasets and properties. BioGRID is a freely accessible data- analysis tools. We have developed a biological General base of physical and genetic interactions avail- Repository for Interaction Datasets (BioGRID) to house and able at . BioGRID release distribute comprehen