Air Flow Analysis in Pharmaceutical “Clean Rooms”.ppt

Air Flow Analysis in Pharmaceutical “Clean Rooms” Patrick Phelps ( Flowsolve ) and Richard Rowe ( Clean Room Construction Ltd ) Air Flow Analysis in Pharmaceutical “Clean Rooms” Industrial Context Health and Safety Issues Application to an Existing Room Application to New Ventilation Designs Conclusions Experimental Verification “Clean Rooms” “Clean Rooms” Personnel access controlled 2-layer sterile over-clothing Equipment sterilised before entry Strict cleansing procedures Particular attention to ventilation Ventilation of “Clean Rooms” Design and performance of air supply, filtration, and extraction arrangements must meet exacting standards Positive pressure areas Use of Laminar Flow Units (LFU’s) “ Laminar Flow Units ” Devices which deliver a controlled down-draught of re-filtered air over sensitive regions preparation areas processing areas packaging areas storage areas Air Flow Analysis in Pharmaceutical “Clean Rooms” CFD Application to Air Flow Analysis in “Clean Rooms” Context Upgrade of ventilation system in a suite of “ clean rooms” at a UK pharmaceutical company CFD Application to Air Flow Analysis in “Clean Rooms” Objective Use CFD to ensure exacting requirements can be met , following installation of a number of LFU’s . CFD Application to Air Flow Analysis in “Clean Rooms” Workscope 3 rooms selected as representative examples of areas being upgraded Room 30 Room 23 Room 42 Modelling Considerations - 1 Irregular shaped domains Internal Obstructions to flow Cartesian grid employed K-e (Chen) turbulence model used Buoyancy important in transient (otherwise assume isothermal) Modelling Considerations - 2 Dependent variables solved pressure, p lateral velocity component, U vertical velocity component, V Longitudinal velocity component, W Turbulence kinetic energy, k Turbulence energy dissipation rate, e residence time parameter, tres (temperature, T (for transient) Modelling Considerations - 3 Boundary Conditions Air supply d