Buffers in Blood.Acidosis and Alkalosis. .ppt

Neutralization Lecture PLUS Buffers in Blood.Acidosis and Alkalosis. Chapter 10. Buffers in the Blood The pH of blood is 7.35 – 7.45 Changes in pH below 6.8 and above 8.0 may result in death The major buffer system in the body fluid is H2CO3/HCO3- Some CO2, the end product of cellular metabolism, is carried to the lungs for elimination, and the rest dissolves in body fluids, forming carbonic acid that dissociates to produce bicarbonate (HCO3-) and hydronium (H3O+) ions. More of the HCO3- is supplied by the kidneys. CO2 + H2O ? H2CO3 H2CO3 + H2O ? H3O+ + HCO3- Carbonate buffer H2CO3 + H2O ?