Chapter 50, Figure 6.ppt

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Chapter 50, Figure 6.ppt

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Essentials of Glycobiology Second Edition Chapter 50, Figure 6 Structure of influenza neuraminidase inhibitors Essentials of Glycobiology Second Edition * FIGURE 50.6. Structure of influenza neuraminidase inhibitors. Chemical structure of Neu5Ac, NANA; 2-deoxy-2,3-dehydro-N-acetyl neuraminic acid, DANA; 4-amino-DANA; 4-guanidino-DANA Relenza, zanamivir ; 3R, 4R, 5S -4-acetamido-5-amino-3- 1-ethylpropoxyl -1-cyclohexane-1-carboxylic acid GS4071 ; ethyl ester derivative of GS4071 GS4104, Tamiflu . DANA is thought to resemble the transition state in hydrolysis. The addition of the guanidinium group in Relenza permits higher affinity binding to the active site. Essentials of Glycobiology Second Edition * FIGURE 50.6. Structure of influenza neuraminidase inhibitors. Chemical structure of Neu5Ac, NANA; 2-deoxy-2,3-dehydro-N-acetyl neuraminic acid, DANA; 4-amino-DANA; 4-guanidino-DANA Relenza, zanamivir ; 3R, 4R, 5S -4-acetamido-5-amino-3- 1-ethylpropoxyl -1-cyclohexane-1-carboxylic acid GS4071 ; ethyl ester derivative of GS4071 GS4104, Tamiflu . DANA is thought to resemble the transition state in hydrolysis. The addition of the guanidinium group in Relenza permits higher affinity binding to the active site.