Protein structure Classification.ppt

Protein structure Classification Ole Lund, Associate professor, CBS, DTU. Why classify proteins Number of solved structures grow rapidly Generate overview of structure types Detect similarities (evolutionary relationships) Set up prediction benchmarks Classification schemes SCOP Manual classification (A Murzin) CATH Semi manual classification (C orengo) FSSP Automatic classification (L Holm) Levels in SCOP Class 10 Folds 648 Superfamilies 1007 Families 1699 Murzin et al., 1995 Major classes in scop Classes All alpha proteins Alpha and beta proteins (a/b) Alpha and beta protein