Chapter 14- Mesoderm-paraxial and intermediate.ppt

Chapter 14- Mesoderm-paraxial and intermediate Chapter 14- Mesoderm-paraxial and intermediate Intermediate Mesoderm * Recall lineages: Fig. 12.4 Fig. 14.1- mesoderm lineages Fig. 14.2- mesoderm lineages in chick 24hr 48hr Kidney, gonads 2. __________ Cartilage, skeletal, dermis Head Somites 1. ______ Circulatory, Body cavity, extraembryonic 3. ________ Notochord a. 4 components of somite formation __________________- total number of somites is __ in chicks, __ in mice somites form from ____________ in regular intervals 1. Paraxial mesoderm Fig. 14.3 Neural tube Mechanism? Involves the _______ gene _____ gene expression correlates with positioning of somites This effect is _____________ of all surrounding tissue 2. __________________- mesenchyme is converted to epithelium prior to final somite formation EM proteins fibronectin and N-cadherin link cells into clustered units Cartilage, skeletal, dermis Head Somites 1. Paraxial 4 components of somite formation (cont.) 3. ___________________________ Distinct somites give rise to distinct __________ 1. Paraxial mesoderm Fig. 11.40-Mouse somites mapped to vertebrate regions and to specific_____ gene expression Specific ___ gene expression predicts the type of vertebra formed hox5 Somites hox6 hox9 hox10 4 components of somite formation (cont.) 1. Paraxial mesoderm (cont.) Some somite cells become mesenchymal cells again to form ___________________- these will become _____________ of vertebrae and ribs Fig. 14.7 Sclerotome cells 4. _____________________- somites form cartilage of ____________ and ribs ___________ of rib cage, limbs and back dermis of the dorsal _________ 4 components of somite formation 1. Paraxial mesoderm (cont.) 4. Differentiation- (continued) Fig. 14.9 Somites have three ________________ regions that follow distinct fates: a. _______ c. Body wall __________ b. ______ muscles Sclerotome ___________ produces NT-3 and ____ proteins that influence somite cell fate ____________ produces _____