亚健康失眠人群脑内神经递质水平分析.pdfVIP

24 李绍旦, 杨明会, 王振福, 窦永起, 周登峰 探讨亚健康失眠人群的脑内神经递质 动变化情况及其与失眠程度间的关系 应用脑电 超慢涨落图 EFG 分析仪与匹兹堡睡眠质量指数 PSQI 量表, 检测亚健康失眠人群的 EFG表现和 PSQI总分值 46例亚健康失眠者PSQI总分均 7分, 其中以总分 7~ 16分为主 占 826% EFG检测 - 氨基丁酸 GA- BA 谷氨酸 G lu 5- 羟色胺 5- H 乙酰胆碱 A ch 去甲肾上腺素 NE 及多巴胺 DA 的水平都低于 参考值, 与参考值比较差别均有统计学意义 P 005 反映失眠程度的PSQ I总分值与神经递质中的GABAGlu水 平间均具有线性相关性, 其中与GABA 的相关系数 r - 0967, P 001; 与 G lu的相关系数 r - 0639, P 005 亚健康失眠者脑内主要神经递质均明显降低, 其中GABA和 G lu 动异常与失眠程度间有密切关系 入睡和睡眠障碍; 神经递质; 脑图 R 33814 A 1007- 9572 2008 1A- 0024- 03 Analysis of theLevelofNeurotransm itters of Sub- Healthy People with Insomnia LI Shao - dan, YANGM ing - hui, WANG Zhen- f u, et al. Institute of TraditionalChineseM edicine, General osp ital of PLA, Beijing 100853, China Abstract Objective o investigate the changes of main neurotransm itters in the brain of sub- healthy people w ith insomnia and the relationship betw een the levelof neurotransmittersw ith the degree of insomnia. M ethods Detecting the neuro - transm itters changes and the Pittsburgh Sleep Quality Index PSQI values of 46 sub- healthy people w ith insomnia by En- cephalonuctuogram EFG technique and PSQI scale respectively. Results PSQ I value of each insomniacsw as equal to or ex- ceeded 7, and the value of themost accounting for 82. 6% was between 7 and 16. he neuro- transm itters levels of- a- m ino- butyric acid GABA , G lutamate G lu , Serotonin 5- H , A cetylcholine A ch , Norepinephrine NE andDo- pam ine DA w ere all declined obviously P 005 . he changes of GABA and G lu w ere significantly correlated w ith the value of PSQ I r - 0967, P 001; r - 0639, P 005 respectively . onclusion M ain neurotransm itters in the brain of sub- healthy peoplew ith insomnia are decreased obviously. GABA andG lu play very mi portant roles in the aggravation of insomnia. Keyword Sleep initiationmaintenance disorders; N eurotransm itters; Brainmapping , 11 20068~ 2007 1 , 46, 27 , 19; [ 1]