肠杆菌科细菌对头孢曲松耐药趋势国内文献分析.pdfVIP

肠杆菌科细菌对头孢曲松耐药趋势的国内文献分析 1 2 陈昭丽 王霆 （1.中南大学药学院药物分析教研室，长沙410013；2. 湘北威尔曼制药有限公司，长沙410329） 摘要：目的：了解我国2000 年以来各地区肠杆菌科细菌对头孢曲松的耐药趋势。 方法：检索中国期刊全文数据库，筛选质量合格文献，文献中的数据按不同地区、 不同年份、不同种类肠杆菌科细菌菌株进行归类、计算和分析。结果：共筛选文 献68 篇。经分析，不同年份、不同地区以及不同种类肠杆菌科细菌对头孢曲松 的耐药率存在差异。肠杆菌科细菌、大肠埃希菌和肺炎克雷伯杆菌耐药率呈上升 趋势，2000-2008 年9 年间分别增长了13.3%，18.4 %和18.8%。肠杆菌科细菌耐 药率与ESBLs(+)检出率增加密切相关，而ESBLs(-)菌对头孢曲松的耐药率保持 在较低水平，但2005 年来有增长趋势。结论：2000-2008 年我国临床分离肠杆菌 科细菌对头孢曲松的耐药率呈上升趋势，其耐药率的增长可能主要由ESBLs 菌 的流行所致，其次同ESBLs(-)菌耐药率升高有关。 关键词 头孢曲松；耐药率；肠杆菌科细菌； 超广谱β- 内酰胺酶 Analysis on ceftriaxone resistance of Enterobacteriaceae based on domestic literatures 1,2 1,2 2 3 1,2 CHEN Zhao-li ,ZHANG Xin-yan ,LI Chang-qing ,WANG Guang-ji ,WANG Ting * (1. Department of Biopharmaceutics，College of Pharmacy, Central South University, Changsha, Hunan 410013; 2. Xiangbei Welman Pharmaceutical Co. Ltd, Changsha 410000; 3. China Medicine University,Nanjing,Jiangsu,210009) Analysis on ceftriaxone resistance of Enterobacteriaceae based on domestic literatures [Abstract] Objective: To investigate the situation and tendency of ceftriaxone resistance to clinical isolates of Enterobacteriaceae . Methods:The references related to ceftriaxone resistance were gathered by the CNKI datebase. The resistance rates of different strains of bacteria were assayed in various regions and years. Results: The results showed that the resistant rates of each strains of Enterobacteriaceae 、 Escherichia coli, and Klebsiella pneumonia had been increasing by 13.3%, 18.4% and 18.8% in last nine years basing to 68 scientific references eventually chosen. There is a positive correlation between the resistance rates to cefriaxone and detection rate of ESBLs-producing Enterobacteriaceae, meanwhile the resistance r