电针治疗对糖尿病伴发周围性面瘫的作用与机制探讨.docVIP

电针治疗对糖尿病伴发周围性面瘫的作用及机制探讨 作者 作者单位 夏辉 湖北省浠水县人民医院四内科 徐桂华　　 湖北省浠水县人民医院一内科 [ABSTRACT] Objective： To observe the role and mechanism of electro-acupuncture treatment of diabetic peripheral facial paralysis. Methods：A total of 68 patients with diabetic peripheral facial paralysis were randomly divided into control group and observation group. The control group was given routine endocrine therapy， while the observation group was given electro-acupuncture treatment based on the conventional treatments. Curative effects， serum malondialdehyde (MDA) concentration， superoxide dismutase (SOD)， nitric oxide synthase (NOS) concentration and nitric oxide (NO) concentration， iNOS and eNOS concentration， as well as immune function associated IgA， IgM and IgG levels were compared between the two groups. Results：The effective rate of the observation group was 89%， significantly higher than 65% of the control group (P0.05). Levels of serum SOD， NO， NOS and eNOS were higher in the observation group， than that in the control group; while serum MDA and IgG， IgA levels were significantly lower than that of the control group.Conclusions：Conventional treatment combined with electro-acupuncture treatment shows better curative effects than the conventional treatment， it might be related with the regulation function of electro-acupuncture for the SOD， MDA， NO， NOS， IgG and IgA content. [KEY WORDS] Electro-acupuncture; Diabetes; Peripheral facial paralysis 面瘫，俗称口僻，现代医学称为面神经炎或面神经麻痹。面瘫的划分尚无统一标准，临床上的分型大致有风热内侵、气血失养、风寒闭阻、瘀血阻滞等类型。现代医学认为本病分为两类，其中周围性面瘫是由于茎乳突孔内组织发生炎性水肿压迫面神经所致，而中枢性面瘫是由于脑部炎症、肿瘤压迫脑血管疾患所致。糖尿病伴发的周围性面瘫病情较重、疗程长且容易留下后遗症。西医治疗主张早期使用激素以及改善血液循环、营养神经、抗病毒的药物，但疗效往往不尽人意，且激素治疗还产生许多副作用[1-2]。研究报道针刺特别是电针治疗面瘫效果显著，本研究观察了电针治疗糖尿病伴发周围性面瘫的疗效，并探讨可能的机制。 1　资料与方法 1.1　一般资料 糖尿病伴发周围性面瘫患者68例，面瘫病程≤7 d，其中男性36例，女性32例，年龄43～61岁，平均年龄54.5岁，体重54～75 kg。随机分为观察组和对照组，每组34例。两组患者在年龄比、身高、体重方面无显著差异(P0.05)。 1.2　纳入标准 (1)周围性面瘫的诊断标准：参照《神经病学》及国家中医药管理局《中医病证诊断疗效标准》中周围性面瘫的诊断标准[2-3];