chp05 Analysis of Aromatic acid课件.pptVIP

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chp05 Analysis of Aromatic acid课件.ppt

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CHAPTER 5 ANALYSIS OF AROMATIC CARBOXYLIC ACIDS GENERAL CONSIDERATIONS In this chapter we will learn the analysis of aromatic carboxylic acids (to aromatic ring connected with carboxyl group) and their salts, aromatic esters, and substituted aromatic carboxylic acids such as : acetyl-salicylic acid (Aspirin), sodium para- Aminosalicylate benzoic acid, sodium benzoate benorilate （贝诺酯）, etc. Salicylic acids salicylic acid Aspirin sodium para-aminosalicylate Benzoic acids benzoic acid sodium benzoate Other aromatic acids benorilate（贝诺酯） Section 1 Analysis of Salicylic Acids 5.1.1 Properties: 1. alkali metal salts of aromatic acid dissolve in water, free aromatic acids are soluble in organic solvents (alcohol, chloroform, and ether ), but slightly or hardly soluble in water 2. aromatic acids were classified into the mild strong acid (pKa=3~6) mineral acid (HCl, H2SO4) aromatic acid carbonic acid (pKa6.3) phenols (pKa9.95) aromatic acid may make carbonate, hydrocarbonate yield carbon dioxide gas, but phenols do not. ——to distinguish aromatic acids and phenols ——to identify salt of aromatic acid drugs by melting point of aromatic acids (decomposed product under the strong acid solution) 3. aromatic esters may hydrolysis especially under the excess alkali. ——assay: after alkaline hydrolysis (excess alkali volumetric solution, VS), back titration with acid volumetric solution, VS. 4. substituted aromatic acids hydroxyl group on benzene ring —— ferric chloride, such as colored ferric salicylic acid complex amino-group on benzene ring —— diazotisation (sodium nitrite titration) may be used for assay —— diazo coupling reaction (with ?- naphthol) may be used for identification 5.1.2 Identification: 1. The reaction with ferric chl