TGA测定克拉霉素热分解动力学参数.pdfVIP

2009 7 34 7 419 : 1001-8689( 2009) 07-0419-03 TGA 李玮 (安徽省食品药品检验所, 合肥 230051) : (TGA ), Ozawa, , , , , ( Cn ), 0. 9998597E n A 148. 1111 1. 3750 10. 5158, k 1. 4306 : ; ; : R927. 11 : A Determination ofclarithromycin thermaldecomposition kinetic parameterswith thermogravimetry analysis L iW ei (An ui Institu te for Food and Drug Control, H efei 230051) ABSTRACT TG ( t ermogravmi etry)-DTG ( differential t ermogravmi etry) w ere app lied to determ ine t e t ermal decomposition curves of clarit romycin . O zaw amet od andmultivariate linear regression m et odw ere used to determ ine t e t ermal decomposition function and equation, and iso-t ermal test w as used for validation. T e process of t e t ermal decomposition of clarit romycinw as close to type Cn ( n-t order w it autocatalysis) w it regression coefficient 0. 9998597. T e activation energy (E ) w as 148. 1111 kJ /mol, t e order of reaction ( n ) w as 1. 3750, t e logarit m of preexponential factor (A ) w as 10. 5158 and t e autocatalytic constant (k ) w as 1. 4306. T is study provided t eoretical foundation for t e t ermal stab ility evaluation and quality mon itoring of clarit romycin. KEY ORDS Clarit romycin; T ermogravmi etry; T ermal decomposition kinetics ( clarit romycin) 6-O- 1 , 14, 209F3(N etzsc ), , , , [ 1] , 98. 2% , - 2 , 3. 8~ 4. 2mg, 51015 20 /m in, , 45 ~