2010抑制小胶质细胞激活.pdfVIP

1814 Regular Article Biol. Pharm. Bull. 33(11) 1814—1821 (2010) Vol. 33, No. 11 Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation Yanji CUI,a,e Jinji WU,a,e Sung-Cherl JUNG,a,e Deok-Bae PARK,a,f Young-Hee MAENG,a,g Jeong Yun HONG,a,h Se-Jae KIM,b Sun-Ryung LEE,b Soon-Jong KIM,c Sang Jeong KIM,d and Su-Yong EUN *,a,e a Institute of Medical Science, Jeju National University School of Medicine; e Department of Physiology, Jeju National University School of Medicine; f Department of Histology, Jeju National University School of Medicine; g Department of Pathology, Jeju National University School of Medicine; h Department of Pediatrics, Jeju National University School of Medicine; 66 Jejudaehakno, Jeju-si, Jeju-do 690–756, Republic of Korea: b Department of Biology, Jeju National University; 66 Jejudaehakno, Jeju-si, Jeju-do 690–756, Republic of Korea: c Department of Chemistry, Mokpo National University; 61 Dolim-Ri, Chonggye-Myon, Muan-Gun, Chonnam 534–729, Republic of Korea: and d Department of Physiology and Biophysics, Seoul National University College of Medicine; 28 Yonkeun-Dong, Chongno-ku, Seoul 110–799, Republic of Korea. Received April 20, 2010; accepted August 27, 2010; published online August 30, 2010 A growing body of evidence suggests that nobiletin (5,6,7,8,3,4-hexamethoxy flavone) from the peel of cit- rus fruits, enhances the damaged cognitive function in disease animal models. However, the neuroprotective mechanism has not been clearly elucidated. Since nobiletin has shown anti-inflammatory effects in several tis- sues, we investigated whether nobiletin suppresses excessive microglial activation implicated