二氢埃托自身给药对大鼠淋巴细胞功能免疫抑制.pdf

BIBLID：塔s 0253-9756 AdaP|匝珊州 唧cas 曲 中国药理学报 1998 d；19(4)：387—390 Immunosuppressiveeffectsofintravenousselfadmini~,ration ofdihydroetorphineonlymphocytefunctionsinrats wu Wei．Ran2，ZTIFANG 5- ，LIFeng-Yuna，Ⅱ Yin (Depo~mentof Pharmacology， MedicalUnivemity，皿 air710061； NationalIn,titute∞ DrugDependence． iiingMedical University；4Depa~ ofl~ logy，Beiji,~MedicalUnivers~ ，Being100083，China) intravenous self administration (SA) on lymphocytefunctionsinmts． MA唧 IAISAND M旧 mDDS AI~I：To study theeffectsofdihydroeotrphine Maltrials Wistarrats( ，weighing300 (DHE)on lymphocytefunctionsinmts andto ±s20g，clean，Certificate№ 01．3056)were fll~ er assess hte abuse potential of DHE ， suppliedby theExperimentalAnireal Centerof ^伍 HoDS：An intravenousseIfadministmtion BeijingMedical Universitv． D皿 ．suppliedby (SA)procedureinmtswasusedtodeterminethe NationalInsfituteonDrugDependence(NIDD)， SAhabilityofDHE ． ConcanavalinA (ConA)． w踮dissolvedinsaline． fHlThymidine(740 stimulated lymphocyteprolfieration nad lympho． TBq ·mol ) was purchased from Shanghai kine production of rat splenocytes were InstiutteofNuclearResearch，Chinees Academy measured． REsI】I腮 ： D肛 178 ± 13 0fSciences． ConcanavalinA (ConA)and3一 d u．g established a stable nad typical ratmod of 【4，5-dimehtylthiazol-2一ylJ-2，5-diphenyltetrazo- psychologicaldependence， suppressed lympho- hum brorrfide (Mrr)were from Sigma Co． eyteproliferation(129士llB盯)comparedwiht Cytootxic T-lmyphocyte line (CⅡ工 ) was controlgroup (620±36Bq)．nadinhibitde the supplide byDepartmentofImmunologyofBeijing ac tvofinterleukin．2(Ⅱ，2)(m ：0．28± MedicalUniversity． SeIfadministration control 0．06