半乳糖凝集素-3在慢性充血性心力衰竭中临床价值初探及与中医分型相关性的研究.pdfVIP

半乳糖凝集素-3 在慢性充血性心力衰竭中的临床价值初探 及与中医分型的相关性研究 上海中医药大学岳阳中西医结合医院心内科 罗海明 史菲 邓中龙 戴健 周迅杰 姚春梅 朱岩峰 摘要：目的：初步探讨半乳糖凝集素-3 （Galectin-3，以下简称Gal-3）在慢性 充血性心力衰竭（CHF）患者中的变化以及与中医辩证分型的相关性。方法：将 133 例心功能II-IV 级的慢性心力衰竭患者按不同心功能等级分为三组，另选取 30 例健康志愿者作为正常对照组。CHF 组于入院后即依据辨证标准，确定中医辨 证类型。所有病例于入院后次日晨抽取静脉血，检测BNP、hs-CRP 及Gal-3。治 疗5-7 天后，其中53 例复测BNP，根据BNP 下降与否分组。结果：心衰组的Gal-3 水平明显高于对照组（P0.01），且随着心衰程度的加重而显著升高。Gal-3 与 BNP、hs-CRP 呈较显著的正相关（r=0.710，r=0.686），与病程之间呈弱相关性 （r=0.390）。Gal-3 对诊断心衰也具有较高的价值。Gal-3 水平与中医各证型之 间具有良好的相关性，且从低到高依次是：气阴两亏证、气虚血瘀证、阳虚水泛 证。结论：血清Gal-3 水平能够客观反地映心衰的程度，与BNP、hs-CRP 具有良 好相关性，在心衰诊断方面也具有一定价值。Gal-3 水平能够客观反映心衰的不 同中医证型的轻重程度，可以作为心力衰竭中医辨证分型的客观化指标。 关键词：慢性充血性心力衰竭；半乳糖凝集素-3 ；B 型脑钠肽；高敏C 反应蛋白； 中医证型 Exploration of Clinical Value of Galectin-3 on Chronic Congestive Heart Failure and Study on relation between Galectin-3 and Syndrome Differentiation of TCM Abstract:Objective :This study is to explore the clinical significance of Galectin-3 in chronic congestive heart failure and its relation with Syndrome Differentiation of TCM.Methods: 133 patients with congestive heart failure were studied and were divided into three groups separately according to NYHA functional classification (from degree II to IV).They were evaluated by syndrome differentiation of TCM.In addition,30 healthy persons were chosen as control group.Plasma levels of BNP,serum levels of hs-CRP and Galectin-3 were measured and analyzed.Result:Galectin-3 levels were significantly higher in subjects with heart failure compared with control group (p0.01).In CHF group,the degree of exacerbation of cardiac insufficiency was in company with the increase of serum concentration of Galectin-3.Blood level of Galectin-3 was strongly positively correlated with concentration of BNP and hs-CRP(r=0.710,r=0.686),but weakly positiv