p53在结直肠癌中的表达和临床意义.pdfVIP

·294· world of TraditionalandwestemMedicine 世界中西医结合杂志2007年第2卷第5期 JournalIntegrated 2007，v01．2，No．5 3在结直肠癌中的表达及临床意义 p5 张艳霞1，王 昱2 1．山西医科大学第一临床医学院病理科，山西太原030001 2．太原市妇幼保健医院病理科，山西太原030001 关系。方法：选用结直肠癌组织标本80例及相应的癌旁组织标本40例，通过免疫组化法检测p53在结直肠 癌组织及癌旁组织中的表达，分析p53在结直肠癌中的表达与结直肠癌临床病理参数之间的关系。结果： 说明p53有可能作为结直肠癌发生、发展及预后的肿瘤标志。 [关键词]结直肠癌；p53；临床病理；免疫组化 [中图分类号]R735．3[文献标识码]B [文章编号]1673—6613(2007)05一0294一03 Cl-niCal and Of inC010rectaICanCer p53 SignifICanceExpresSiOn Yu2 ZhangYanxial，Wang of1stCI．nicalMedical Of 1．PathO——department CO||ege，MedicinaIUnIversity 030001，China ofMaternaIandChiklHeaIth of 2．PathO—department HOspitaITaiyuan，Talyuan，Shanxi the betweenthe of and [Abstract_Jobjective：To expression probereIationship p53 and 80 OfcOIOrectalcancerand40near——cancertissue OpmentprOgnOsis．TⅥethOds：samples samples used．The of wasexaminedindifferent the were expressionp53 groupby were rateOf is66．3％and20．8％incolo卜 parametersanaIysized．Results：ThepOs…veexpressionp53 ectaIcancerandnear——cancertissue were differencebetween respectiveIy．Theresignificant O．0 rateof 3has with andextentofce|| 1)．Thepositiveexpressionp5 correIationlynlphonode——transfer differentiation(F’0．05)，andnoreIationwith and of age p53 was fOrthe and OfcOIOrectaIcancer．1tcouIdbeatumOr—marker． respOnsibIefOrmingdeveIOping CoIor