创伤后应激障碍和其神经内分泌基础研究进展.pdfVIP

当代医学　2009年2月第15卷第4期总第159期　Contemporary Medicine, Feb. 2009,Vol.15 No.4 Issue No.159 创伤后应激障碍及其神经内分泌基础研究进展 张新安 朱宵鹤 石玉秀 [摘要] 创伤后应激障碍，是指由于异乎寻常的威胁性或灾难性心理创伤，导致延迟出现并且长期持续的精神障碍，主要表现为病理性重现、 恶梦惊醒、持续性警觉性增高和回避，以及对创伤经历的选择性遗忘和对未来失去信心等，是近年来在中国精神病学界逐渐引起重视的一种反应性 精神障碍。本文着重从神经内分泌的角度对创伤后应激障碍作以综述。 [关键词] 创伤后应激障碍；神经内分泌；下丘脑-垂体-肾上腺轴；下丘脑-垂体-性腺轴；糖皮质激素 [Abstract] The exposure to an abnormal minatory or catastrophic traumatic event may result in posttraumatic stress disorder (PTSD), which is characterized by a complex symptomatology, such as symptoms of reexperiencing the trauma, hyperarousal, persistent alert augment and eschewal, selective oblivion for traumatic event, losing confi dence, and so on. It is a corresponsive psychic obstacle, and became important in psychiatry, so an increasing number of scholars employ themselves in it. For the effect of social psychologic factors, it is different from normal stress reaction and other lunacies.PTSD was considered as a disease which can be diagnosed independently until 1980. This article will have a introduction on its base of neuroendocrine . [Key Words] posttraumatic stress disorder; neuroendocrine; hypothalamic-pituitary-adrenal axis; hypothalamic-pituitary-gonadal axis; glucocorticoid 综 近年来，随着战争、社会暴力、重大交通事故及自然灾害等 国精神障碍诊断和统计手册（DSM-Ⅲ）首次正式以PTSD取代以