部分睡眠剥夺对大鼠免疫功能的影响.pdfVIP

Journal o Henan Medical University 　Sep.　2001　Vol.36　No.5 ·559 · ＊ 1)■ 2) 1) 1) 1) 1) 1) 章　茜 　阎艳琴 　乔　鹏 　袁义强 　王书春 　张　朝 　王雨若 1) 450052　2)4 50052 ■,43 , , , , : 　　关键词　;;; 中图分类号　R338.68 摘要　:。:SD 22 11 , , 。:A, , , , 。:。 Partial sleep deprivation impairs immune unction in rats 1 ) 2 ) 1 ) 1 ) 1 ) 1) ZHANG Qian , YAN Yanqin , QIAO Peng , YUAN Yiqiang , WANG Shuchun , ZHANG Zhao , WANG 1 ) Yuruo 1 )Department of Ph siolog ,Henan Medical Universit , Zhengzhou 450052 　2 )Zhengzhou Orthopaedics Hos- pital, Zhengzhou 450052 　　Key words　sleep;immune unction;sleep deprivation;rat Abstract 　Aim:To explore the relationship between sleep and immune unction.Met hods:A total o 22 SD rats w ere divid- ed into 2 groups o 11 each:sleep deprivation group and control group.The immunology methods w ere used to observe the changes o the proli erative reactivity o spleen cells and delayed hypersensitivity in rats undergoing partial sleep deprivation.Result s:The data showed that spleen cell proli eration reaction induced by ConA or LPS obviously decreased and unctions o spleen antibody- secreting cells w ere obviou sly suppressed a ter sleep deprivation.Four d a ter sleep deprivation, delayed hypersensitivity w as obvi- ously suppressed.The thymuses and spleens o rats deprived sleep w ere atrophied, and the histology o immune organs had not changed.Conclusion:The study suggests that sleep deprivation can suppress the immune reactions. ＊ ,5-HT , 、, 。 1993.384 ,。 6　, .5-. , 199 1, 22:15 7　.5-.· , 199