人乙醛脱氢酶2基因_1_2多态性和酒精性疾病.pdfVIP

, 2007, 4 ( 2) : 164167 JM ed M o l B io,l 2007, 4 ( 2) : 164167 * * 2 1/ 2 裘丽珍, 钟文涛, 龚兴国 , 3 10058 2 ( ALDH 2) , aldh2 * * , aldh2 2, aldh2 2 , * 2 2; ; ; ; Q 7 1 * Relationship between Human a ldh 2 2 and A lcoholic Diseases Q IU L izhen, ZHONG W entao, GONG X ingguo Institute of Biochem istry, Zhejiang University, H angzhou, 310058, hina Abstract H um an aldehyde dehydrogenases 2 (A LDH 2) is one o f the m ost mi po rtant enzym es * in ethanol m etabo lism Am ong the known aldh2 alleles, the aldh2 2 allele is rare in m ost popu la t ions, but comm on in A sian andM ongolian racesA s an interest ing factor that prevents heavydrink * ing, the aldh2 2 allele he lp s avoid alcoho l dependence to som e degreesR ecent studies show ed that the genetic po lym orph ism s of aldh2 w ere re la ted to a lcoho lic diseases, such as alcoho l dependence, alcoho lism, a lcoho lic liver disease, upper d igest ive tract cancer and stom ach cancer * K ey words aldh2 2, alcoho l dependence, a lcoholic liver disease, upper digest ive tract canc er, stom ach cancer ( aldehyde dehydrogenase, A LDH ) * 1 a ldh 2 (a ldh2 2) ( a lcohol dehydrogenase, ADH ) , aldh2 12 ( 12q242 ) [ 13] 487