胃食管反流病的定义和治疗.pdf

American Journal of Gastroenterology ISSN 0002-9270 C 2006 by Am. Coll. of Gastroenterology doi: 10.1111/j.1572-0241.2006.00630.x Published by Blackwell Publishing CME The Montreal Definition and Classification of Gastroesophageal Reflux Disease: A Global Evidence-Based Consensus Nimish Vakil, M.D., F.A.C.G., 1 Sander V. van Zanten, M.D.,2 Peter Kahrilas, M.D.,3 John Dent, M.D.,4 Roger Jones, M.D.,5 and the Global Consensus Group 1 University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin and Marquette University College of Health Sciences, Milwaukee, Wisconsin; 2Dalhousie University, Halifax, Nova Scotia, Canada; 3Northwestern University, Chicago, Illinois; 4 University of Adelaide, Adelaide, Australia; and 5Kings College, London, United Kingdom OBJECTIVES: A globally acceptable definition and classification of gastroesophageal reflux disease (GERD) is desirable for research and clinical practice. The aim of this initiative was to develop a consensus definition and classification that would be useful for patients, physicians, and regulatory agencies. METHODS: A modified Delphi process was employed to reach consensus using repeated iterative voting. A series of statements was developed by a working group of five experts after a systematic review of the literature in three databases (Embase, Cochrane trials register, Medline). Over a period of 2 yr, the statements were developed, modified, and approved through four rounds of voting. The voting group consisted of 44 experts from 18 countries. The final vote was conducted on a 6-point sca