武威汉简瘀方联合贝那普利治疗血瘀型糖尿病肾病68例.docVIP

武威汉简瘀方联合贝那普利治疗血瘀型糖尿病肾病68例 　　作者：李 蔚1，傅松波2，范 力1，杨 瑞1，魏淑萱1 作者单位：1 730050 甘肃兰州，兰州市中医医院　2 730000 甘肃兰州，兰州大学第一医院 　　【摘要】 目的 观察武威汉简瘀方联合盐酸贝那普利片治疗血瘀型糖尿病肾病的临床疗效。方法 筛选糖尿病肾病患者血瘀型190例，采用随机分组，对照组62例，中药组60例，中西医结合组68例，三组均给予常规和对症治疗，对照组给予盐酸贝那普利片10mg，每日1次;中药组服用甘肃武威汉简瘀方，并随症加减，治疗3个疗程;中西医结合组在服用盐酸贝那普利的基础上加服中药武威汉简瘀方，每日1剂，治疗3个疗程后观察疗效。结果 三组患者临床疗效比较，对照组总有效30例,总有效率48.4%;中药组60例，总有效51例，总有效率86.7%;中西组68例，总有效66例，总有效率97.1%，经统计学处理，中西医结合组有效率明显高于对照组(P0.05)。三组治疗前后FBG(空腹血糖值)、HbAlc(糖化血红蛋白值)变化和UAER(尿微量白蛋白排泄率)、BUN(尿素氮)、SCr(肌酐)比较，三组治疗后FBG、HbAlc UAER 、BUN以及 SCr均有下降，与本组治疗前比较差异有统计学意义(P0.05),中西医结合组治疗后与对照组、中药组治疗后比较差异有统计学意义(P0.05)。三组患者治疗前后中医症状评分改善情况比较，中药组和中西医结合组临床症状均较治疗前显著改善(P0.05)，中西医结合组除舌红少苔和脉沉细弱外，与对照组和中药组治疗后比较差异均有统计学意义(P0.05)。结论 武威汉简瘀方联合盐酸贝那普利治疗糖尿病肾病效果良好，无明显副作用，有临床推广价值。 　　【关键词】 武威汉简瘀方;盐酸贝那普利;血瘀型;糖尿病肾病 　　【Abstract】 Objective To observe the curative effect on treating blood stasis type of diabetic nephropathy with the prescription of combining the Hanjian yufang from Gansu wuwei and Benazepril Hydrochloride Tablets.Methods Selected diabetic nephropathy patients of blood stasis type 190 cases and randomly divided them into three groups: control group (CG), Chinese medicine group (CHMG), and integrative group of Chinese medicine and western medicine (IG), among which CG gets 62 cases, CHMG gets 60 cases, and IG gets 68 cases. The three groups all received symptomatic treatment and routine treatment: CG takes Benazepril Hydrochloride Tablets of 10mg once a day; CHMG takes Hanjian yufang from Gansu wuwei for 3 courses according to symptoms to determine dosage; IG takes Hanjian yufang from Gansu wuwei a dose per day for 3 courses on the basis of taking Benazepril Hydrochloride Tablets, and then observed the curative effect.Results Comparing the clinical effect on three groups patients, CG got 30 cases cure and its general effective rate was 48.4%; CHMG got 51 cases cure and its general effective rate was 86.7%; IG got 66 cases cure and its general effective rate was 97.1%. Processed statistically, the effec