肾小球滤过率估测值评判老年高血压及2型糖尿病并发终末期肾病患者血红蛋白浓度的变化.doc

肾小球滤过率估测值评判老年高血压及2型糖尿病并发终末期肾病患者血红蛋白浓度的变化 　　作者：巩玲俊　 李刚 牟 杨 朱炳豹 作者单位：(重庆医科大学附属第一医院老年科心血管病组，重庆 400016) 　　【摘要】 目的 探讨用肾小球滤过率估测值(eGFR)评判的老年高血压及2型糖尿病并发终末期肾病 (ESRD)患者血红蛋白(Hb)浓度改变。方法 收集高血压及2型糖尿病并发慢性肾病且≥60岁患者230例，将eGFR15 ml·min-1·1.73 m-2(7.80±3.14 ml·min-1·1.73 m-2)者归为ESRD组，eGFR≥15 ml·min-1·1.73 m-2( 29.76±12.90 ml·min-1·1.73 m-2)者归为非ESRD组，回顾性比较两组间Hb浓度。结果 较非ESRD组〔Hb(100.8 ± 23.0)g/L〕，ESRD组Hb浓度〔(74.4 ± 22.5)g/L〕显著降低(P0.05)，且在ESRD与非ESRD组中eGFR均与Hb浓度显著正相关(P0.05)。结论 eGFR评判的老年高血压及2型糖尿病并发ESRD患者Hb浓度显著降低,且eGFR与Hb浓度具有显著正相关性。 　　【关键词】 高血压;2型糖尿病;终末期肾病;肾小球滤过率;血红蛋白浓度 　　Study of change of plasma hemoglobin concentration in elderly patients with primary hypertension and/or type 2 diabetes complicated with endstage renal disease determined by estimated glomerular filtration rate 　　GONG LingJun, LI Gang, MU Yang, et al. 　　Division of Cardiology, Department of Geriatrics, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China 　　【Abstract】 Objective To study the change of plasma hemoglobin(Hb) concentration in elderly patients with primary hypertension and/or type 2 diabetes (T2DM) complicated with endstage renal disease(ESRD) determined by estimated glomerular filtration rate(eGFR). Methods Two hundred thirty cases of patients aged 60 years or older with primary hypertension and/or T2DM complicated with chronic renal disease were enrolled. Patients with chronic renal disease were divided into ESRD group with eGFR less than 15 ml·min-1·1.73 m-2 (7.80±3.14 ml·min-1·1.73 m-2)and nonESRD group with eGFR not less than 15 ml·min-1·1.73 m-2 〔(29.76±12.90) ml·min-1·1.73 m-2〕. Hb concentration was compared between the above two groups retrospectively. Results Compared with nonESRD group〔(Hb 100.8 ± 23.0)g/L〕 there was significant decrease in Hb concentration 〔(74.4 ± 22.5)g/L〕 in ESRD group(P0.05); eGFR was positively related to Hb concentration in ESRD and nonESRD groups respectively(P0.05, for both). Conclusions There is significant decrease