正交试验优化人参的微波灭菌工艺研究.pdfVIP

现代药物与临床 Drugs Clinic 第 27 卷 第 1 期 2012 年 1 月 • 27 • 正交试验优化人参的微波灭菌工艺研究 1, 2, 3 1, 2, 3 1, 2, 3 1, 2, 3 4 1, 2, 3* 吴建雄 ，曹光环 ，秦建平 ，王振中 ，朱跃飞 ，萧 伟 1. 江苏康缘药业股份有限公司，江苏 连云港 222001 2. 中药制药过程新技术国家重点实验室，江苏 连云港 222001 3. 江苏省企业院士工作站，江苏 连云港 222001 4. 连云港康宝鹿业有限公司，江苏 连云港 222000 摘 要：目的 优选人参药材微波灭菌工艺。方法 以灭菌率为指标，采用正交试验对药材粒度、灭菌时间、灭菌功率进行 考察，并考察微波灭菌对人参皂苷的影响。结果 筛选出最佳微波灭菌工艺：灭菌时间 240 s 、人参药材粒度为细粉（10 目）、 灭菌功率 6 000 W 。结论 优选的工艺灭菌效率高，简便可行。 关键词：人参；微波；灭菌；正交试验；灭菌率 中图分类号：R282.4 ；R286.02 文献标志码：A 文章编号：1674 - 5515(2012)01 - 0027 - 04 Sterilization technology optimization of Ginseng Radix et Rhizoma with microwave by orthogonal test 1,2,3 1,2,3 1,2,3 1,2,3 4 WU Jian-xiong , CAO Guang-huan , QIN Jian-ping , WANG Zhen-zhong , ZHU Yue-fei , XIAO Wei1,2,3 1. Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China 2. State Key Laboratory of Pharmaceutical Process New-tech for Chinese Medicine, Lianyungang 222001, China 3. Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China 4. Lianyungang Kangbao Deer Industry Co., Ltd., Lianyungang 222000, China Abstract: Objective To optimize the sterilization technology of Ginseng Radix et Rhizoma with microwave. Methods The sterilization rate was used as the index to evaluate the technologies based on orthogonal test, in which the powder particle size of Ginseng Radix et Rhizoma, sterilization time, and microwave power were considered as three main technology factors, and the contents of ginsenosides were observed. Results The optimum condition was as follows: sterilization time 240 s, the powder particle size 10 mesh, and microwave power 6 00