COX_2和p53在乳腺癌组织中的表达及其相关性.pdfVIP

2006 2 13 4 CHIN J CANCER PREV TREAT , February 2006, Vol. 13 No.4 287 临床研究 COX-2 p53 李莉, 祝峙, 方国恩, 施俊义, 盛援 第二军医大学附属长海医院( 普外科:李莉, 方国恩,施俊义, 盛援; 病理科: 祝峙) 上海200433 Expression and correlation of COX-2 and p53 in human breast cancer LI L i, ZH U Sh i, FA N G Guo-en, S H I J un-y i , S H EN G Y uan Second M ilitary M edical Univ er sity A iliated chang hai H osp ital, Shang hai 200433, P . R . Ch ina : 研究乳腺癌中环氧化酶-2(cy- [ABSTRACT] OBJECTIVE : T o investigate the expression and clooxygenase-2,COX-2) 和 p53 的表达及其相关 correlation of cyclooxygenase ( COX-2) and p53 in hu an breast 性: 用免疫组织化学法检测48例乳腺 cancer. METHODS: Forty-eight cases of breast cancer were de- 癌组织中COX-2 与p53 的表达情况,分析其相 tected by i unohistoche istry for the expressions of COX-2 互间关系及与乳腺癌临床病理学特征间的联 and p53 and the relationship between COX-2 and p53 was ana- 系:乳腺癌中COX-2 表达阳性率604% lyzed together with the clinicopathologic characteristics. RE- (29/ 48) COX-2高表达与肿块 2 c 淋巴结 SULTS: COX-2 was expressed in 604% of thebreast cancer and 转移阳性ER 阴性PR 阴性显著相关, 而与患 the over expression correlated with the factors such as tu or lar- 者年龄肿瘤病理类型及肿瘤分期无明显关系 ger than 2c , ly ph node estastasis, negative ER and PR, and 在p53 阳性的乳腺癌患者中COX-2 表达阳性率 had no relations with the age, the pathologic type and the T NM 826%( 19/23), 而 p53 阴性的乳腺癌患者中, stage. The expression rate of COX-2 in p53 positive breast canc- COX-2 表达阳性率只有400%( 10/ 25),两者相 ers was 826%, significantly higher than that in p53 negative 比有统计学意义,P = 0006: COX-2 在乳 breast cancers, which is only 40%( 10/ 25). CONCLU SION: The 腺癌中高水平表达且与p53 密切相关,提示乳腺 expression of COX-2 is significantly related to the expression of 癌中COX-2与p53 存在互相调控机制, 共同促 p53, which indicates that COX-2 and p53 can regulate each ot