3_氯_2_羟丙基三甲基氯化铵的自催化合成及其合成条件优化.pdfVIP

30 2005 3- -2- 1, 2 1* 2 2 2 , , , , ( 1. , 210009; 2. , 224003) : 以盐酸三甲胺和环氧氯丙烷为原料, 利用正交实验的方法合成了活性阳离 醚化剂3- 氯- 2-羟丙基三甲基氯化铵( CHPTA) , 通过水蒸汽蒸馏和正丙醇重结晶的方法有效提高了CHPTA 产品 的纯度; 并用元素分析熔点测定红外光谱分析及核磁共振分析的方法对产物进行分析和表征 正交实验的结果表明反应温度和反应时间对CHPTA 的收率影响较大, 优化的合成条件为反应2 h, 反应温度35 C, 环氧氯丙烷三甲胺盐酸盐的摩尔比为1. 1, 在此条件下CHPTA 的收率可达96%以 上 : 3- 氯-2-羟丙基三甲基氯化铵; 自催化合成; 阳离 醚化剂; 条件优化 : O 636. 12 :A : 0367-6358( 2005) 01-030-04 Study n the Aut catalytic Synthesis f 3-Chl r -2-hydr xypr pyl Trimethylamm nium Chl ride and the Optimizati n f Synthesis C nditi ns 1,2 1* 2 2 2 CAI Zha-sheng , WANG Jin-tang , YANG Chun-sheng , XU Qi , YANG Jin-l ng (1 . School of Science, Nanj ing University of Technology, Jiangsu Nanj ing 210009, China; 2 . epartment of Chemical Industry, Yancheng Institute of Technology, Jiangsu Yancheng 224003, China) Abstract: The 3-chl r-2-hydr xypr pyl trimethylamm nium chl ride ( CHPTA ) as active quaternary agent f r etherificati n was synthesized thr ugh rth g nal meth d with trimehylamine hydr chl ride and epichl r drin as raw material. The purity f CHPTA pr duct was creased by steam distillati n and recrystallizati n. The pr duct was tested by 1 elemental analysis, IR melt-p int analysis and H NMR. The result f rth g nal experiment indicated that the reacti n temperature and time have significant effect n the yield f pr duct . The ptimum c nditi ns were: reacti n time, 2 h, reacti n temperature, 35 C, m le rati f epichl r drin t trimethylamine hydr chl ride, 1. 1. Under ptimum c nditi ns, the yield f CHPTA may be ab ve 96%