内皮脂肪酶与冠心病的相关性研究.docVIP

内皮脂肪酶与冠心病的相关性研究 内皮脂肪酶与冠心病的相关性研究 作者：成丽英，边云飞 ，杨晓静 ，赵 欣，肖传实 作者单位：山西医科大学第二临床医学院，太原 030001 【摘要】 目的 检测冠心病患者血浆内皮脂肪酶（EL）水平，探讨EL与冠心病的相关性。 方法 选取81例冠心病患者，并根据临床表现分为稳定性心绞痛（SAP）（n=18）、不稳定性心绞痛（UAP）（n=23）、急性心肌梗死（AMI）（n=21）及对照组(n=19)。所有患者分别进行病史采集，并检测空腹血糖（FBG）、血脂、高敏C反应蛋白（hsCRP）、EL水平，分析EL与年龄、性别、吸烟比例、HDLC、LDLC、FBG、hsCRP及冠状动脉病变程度的相关性。 结果 对照组血浆EL水平为（346.4±54.3）Μg/L，而SAP组、UAP组、AMI组分别为：（693.2±89.7）Μg/L、（780.3±99.2）Μg/L、（962.5±123.3）Μg/L，各组间EL水平比较差异有统计学意义(P＜0.05)；EL与HDLC、LDLC、FBG及hsCRP明显相关（P＜0.05)；Gensini评分SAP组分别与UAP组、AMI组比较，差异有统计学意义（P＜0.01)，冠心病组EL平均水平与冠状动脉狭窄程度Gensini平均评分呈正相关（r=0.483，P＜0.01)。 结论 冠心病患者体内EL表达明显增高，EL在冠心病的发生中可能起一定的作用。 【关键词】 内皮脂肪酶； 冠心病 Correlation study of endothelial lipase to coronary heart disease CHENG Liying1, BIAN Yunfei2,YANG Xiaojing2, ZHAO Xin1, XIAO Chuanshi2. 1.Second Clinical Medical College of Shanxi Medical University, Taiyuan 030001; 2. Second Affiliated Hospital of Shan Xi Medical University, Taiyuan 030001, China Abstract：Objective To investigate the correlation between plasma endothelial lipase (EL) level and coronary heart disease (CHD). Methods A total of 81 patients were enrolled and divided into four groups: stable angina pectoris group (SAP, n=18), unstable angina pectoris group (UAP, n=23), acute myocardial infarction group (AMI, n=21) and control group (n=19). Clinical history was collected and fasting blood glucose（FBG）, highdensity lipoproteincholesterol(HDLC), lowdensity lipoproteincholesterol(LDLC), high sensitiveC reactive protein(hsCRP) levels were determined. Relevance of EL to age, sex, smoking proportion, HDLC, LDLC, FBG, hsCRP levels and coronary lesion was analyzed. Results Plasma EL level was (346.4±54.3) Μg/L in the control group, (693.2±89.7) Μg/L in SAP group, (780.3±99.2) Μg/L in UAP group and (962.5±123.3) Μg/L in AMI group. The differences among the four groups were statistically significant (P＜0.05). Significant correlation between EL level and HDLC, LDLC, FBG a