冰片对人参皂苷Rg1鼻腔吸收的促进作用及鼻腔纤毛毒性研究.pdfVIP

Rg1 1 1* 2 3 陈新梅 , 朱家壁 , 孙卫东, 张立建 ( 1 , 210009; 2 , 83005 ; 3 , 135118) : 探讨人参皂苷Rg1 的鼻腔吸收冰片的促进吸收作用及对鼻腔 毛的毒性 采用在体蟾蜍上腭法研究药 物对 毛运动的影响; 采用大鼠在体鼻腔循环法研究人参皂苷Rg1鼻腔吸收的特性及冰片对其吸收的影响; 采用扫描电镜观 察人参皂苷Rg1 及冰片对大鼠鼻腔 毛的急性毒性 循环液中人参皂苷Rg1 的含量为 100, 250, 500 mgL- 1 时, 鼻腔的 吸收速度常数分别为0000 30, 0000 0 和0000 7 min- 1循环液中含有 10 gL- 1, 2% 和3% 的冰片时, 对250 mgL- 1的人参 皂苷Rg1吸收速度常数分别为0001 9, 0001 2 和0001 3 min- 1 人参皂苷Rg1 能通过鼻腔黏膜吸收, 对 毛无毒, 10 gL- 1的冰片对其吸收有促进作用 :人参皂苷Rg1; 冰片; 鼻腔吸收; 毛毒性 : R965 :A : 1001- 2 9 ( 2006) 0 - 0261- 0 Effect of Absorption Enhancer of Borneol on Ginsenoside Rg1 and the Nasal Ciliotoxicity 1 1* 2 3 CHEN Xinmei , ZHU Jiabi , SUN Weidong , ZHANG Lijian ( 1Pharmaceutical Research Institute, China Pharmaceutical University, Nanj ing 210009, China; 2Xinj iang Tef eng Pharmaceutical Co, Ltd , Urum i 83005 , China; 3 Jilin H ongj iu Biotech CoLtd, Tonghua 135118, China) ABSTRACT: OBJECT VE To investigate the nasal absorption of ginsenoside Rg1 and the absorption enhancen effect of borneol METH ODS The effect of ginsenoside Rg1 and borneol on cililary movement were evaluated by in situ toad palate model Nasal circulatory perfusion test in vivo was employed to investigate the characteristics of nasal mucosa absorption ginsenoside Rg1 in rats The electron microscope scan ning technique was used to evaluate the nasal ciliotoxicity of ginsenoside Rg1 and borneol on the nasal mucosas of the ratsRESULTS When the concentrations of ginsenoside Rg1 were 100, 250, 500 mgL- 1, respectively, the corresponding values of the absorption rate were 0000 30, 0000 0 and 0000 7 min- 1However, when the concentration of ginsenoside Rg1was 250 mgL- 1in circulation liquid, the absorption rates were 0001 9, 0001 2 and 0001 3 min- 1 with the aid of borneol of 10, 20 and 30 gL- 1CONCLUS ON Ginsenoside Rg1 can be ab sorbed through the nasal mucous and borneol can enhance the absorption