哈萨克族高血压患者血清中血管紧张素转换酶水平的测定及临床研究.docVIP

哈萨克族高血压患者血清中血管紧张素转换酶水平的测定及临床研究 　　作者：哈德尔别克，赵雪梅，王 勇，王 丽，赵文丽，朱建兵 作者单位：833200 新疆伊犁，伊犁州奎屯医院心血管内科 　　【摘要】 目的 探讨新疆北疆地区哈萨克民族血清中的血管紧张素转换酶(ACE)的浓度水平及临床价值。方法 收集我院2004~2005年未接受血管紧张素转换酶抑制剂(ACEI)类药物治疗，且符合JNC-Ⅵ诊断标准的原发性高血压患者206例，其中哈族100例，汉族106例，哈族患者平均年龄(45.62±13.44)岁，汉族(56.31±11.55)岁，病史1~22年，同时无高压病史及血压正常者为正常对照组84例(哈族40例，汉族44例)进行比较研究。结果 哈、汉两民族高血压患者组血清中ACE差异有统计学意义(P0.05)，哈族高血压病组与正常对照组、汉族高血压病组与正常对照组之间差异有统计学意义(P0.05)。哈、汉两族正常对照组之间差异有统计学意义(P0.05)，哈族正常对照组血清中ACE水平比汉族正常对照组中ACE水平高2倍之多。结论 哈汉两族高血压患者血清中ACE水平有明显差异，且正常组哈族人群血清ACE水平明显高于汉族人群。这可能是哈族高血压发病较早，发病率较高的一种原因，尚有待于进一步研究。 　　【关键词】 哈萨克族;汉族;高血压;血管紧张素转换酶 　　Clinical value on serum ACE levels of Kazak people in north of Xinjiang region 　　Hadeerbieke,ZHAO Xue-mei,WANG Yong,et al.Department of Cardiovascular Medicine,Kuitun Hospital of Yili,Xinjiang 833200,China 　　[Abstract] Objective To investigate the clinical value of serum ACE levels of Kazak and Han people in north of Xinjiang region.Methods There were 206 hypertensive patients with hypertensive history of 1 to 22 years who did not take any ACEI from 2004 to 2005.There were 100 Kazak people,means age was(45.62±13.44)years,and 106 Han people,means age was(56.31±11.55)years.The diagnosis of essential hypertension was according to the standards of JNC-VI.There were other 84 persons(40 Kazak and 44 Han people)who had normal blood pressure without hypertensive history as a control.Results There was significant difference of serum ACE levels between Kazak and Han people(P0.05).The serum ACE levels of Kazak and Han hypertensive people were significantly higher than the normal controls respectively(P0.05).In normal controls,the serum ACE levels were twice higher in Kazak than in Han people(P0.05).Conclusion There is a significant difference of the serum ACE levels in hypertension between Kazak people and Han people.And the serum ACE levels of normal Kazak people are significantly higher than normal Han people.The early onset and high incidence rate of hypertension in Kazak may be due t