吉非替尼联合XELOX方案化疗治疗转移性大肠癌的临床观察《现代肿瘤医学》ISTIC2012年11期.pdf

·2354· 肖 塞，笠 壹韭鲞屋壁盒墨垦垦Q茎立塞丝痘渔痘拭整丝太题瘗盟!堕压理塞 吉非替尼联合XELOX方案化疗治疗转移性大肠癌的临床观察 肖 寒，申小苏，方乃青，朱为民 ClinicalofGefitnibcombinedwith formetastaticcolorectalcancer study chemotherapy XIAO Weimin Han，SHENXiaosu，FANGNaiqing，ZHU TraditionalandWestern No．4 Suzhou Wuxi DepartmentofIntegrated Oncology，Wuxi University，Jiangsu214062， Hospital，够2int．村tO China． observethe and ofGefitnibcombinedwiththe formetastatic 【Abstract】Objective：To efficacysafety chemotherapy Was caseswith coloreetal combinedwithXELOX administratedto30 cancer．Methods：Gefitnib chemotherapyagents metastaticcolorectalcancerconfirmed or ofGefitnibwas byhistopathology imaging。Thedosage 250rag． cytopathology The was and Wasevaluated toRECIST agents Capecitabine．Theefficacy strictlyaccording chemotherapyOxaliplatin Was acuteandsubacute evaluated toWHOanticancer levels．Results：PR criteria．Toxicity according drug toxicity ratewas rateWas rateWas control 76．7％．The toxic rate(DCR)Was 36．7％，SD 40．0％，PD 23．3％，disease major reactionswere tract and combinedwithchemothera- rash．COnclusion：Gefltnib myelotoxicity，gastrointestinaltoxicity inthe colorectalcancer